Application of immunohistochemistry in the diagnosis of epithelioid mesothelioma: a review and update
Application of immunohistochemistry in the diagnosis of epithelioid mesothelioma: a review and update
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DOI：
10.1016/j.humpath.2012.05.014
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发表时间：
2013-01-01
期刊：
影响因子：
3.3
通讯作者：
Ordonez, Nelson G.
中科院分区：
文献类型：
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作者：
Ordonez, Nelson G.
目前有大量的免疫组织化学标记物可以帮助鉴别诊断上皮样间皮瘤。由于这些标记物在可转移至浆膜的各种类型的癌症中表达不同，并且可能与上皮样间皮瘤混淆，因此将它们纳入诊断组的选择很大程度上取决于鉴别诊断，以及哪些标记物在给定实验室中效果最好。传统上，用于鉴别诊断上皮样间皮瘤的组合由阳性间皮瘤标记物和广谱癌标记物的组合组成。目前，有多种器官相关癌症标志物，例如用于肺的甲状腺转录因子-1和napsin A、用于肾的PAX 8和PAX 2以及苗勒氏管衍生的肿瘤；乳腺大体囊性疾病液体蛋白 15 和乳腺珠蛋白；和 CDX2 用于肠道分化，当包含在诊断组中时，可以帮助确定腺癌的起源部位。本文提供了有关各种鉴别诊断中推荐的标记物组组成的最新信息。 (C) 2013 Elsevier Inc. 保留所有权利。
A large number of immunohistochemical markers that can assist in the differential diagnosis of epithelioid mesotheliomas are currently available. Because these markers are expressed differently in the various types of carcinomas that can metastasize to the serosal membranes and can potentially be confused with epithelioid mesothelioma, their selection for inclusion in a diagnostic panel largely depends on the differential diagnosis, as well as on which ones work the best in a given laboratory. Traditionally, the panels used in the differential diagnosis of epithelioid mesothelioma have consisted of a combination of positive mesothelioma markers and broad-spectrum carcinoma markers. At present, a wide variety of organ-associated carcinoma markers such as thyroid transcription factor-1 and napsin A for the lung, PAX 8 and PAX 2 for the kidney, and Mullerian-derived tumors; gross cystic disease fluid protein-15 and mammaglobin for the breast; and CDX2 for intestinal differentiation are available, which can assist in establishing the site of origin of an adenocarcinoma when included in a diagnostic panel. This article provides updated information on the composition of the panels of markers recommended in the various differential diagnoses. (C) 2013 Elsevier Inc. All rights reserved.