Plasma Alkylresorcinol Concentrations Correlate with Whole Grain Wheat and Rye Intake and Show Moderate Reproducibility over a 2-to 3-Month Period in Free-Living Swedish Adults
Plasma Alkylresorcinol Concentrations Correlate with Whole Grain Wheat and Rye Intake and Show Moderate Reproducibility over a 2-to 3-Month Period in Free-Living Swedish Adults
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DOI：
10.3945/jn.111.139238
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发表时间：
2011-09-01
影响因子：
4.2
通讯作者：
Landberg, Rikard
中科院分区：
文献类型：
--
作者：
Andersson, Agneta;Marklund, Matti;Landberg, Rikard
血浆烷基间苯二酚 (AR) 在干预期间可用作小麦和黑麦全麦 (WG) 的膳食生物标志物，但需要在自由生活人群中进行验证。本研究评估了血浆 AR 作为 WG 和谷物纤维摄入量生物标志物的中期再现性和相对有效性。 72 名瑞典成年人两次保存 3 天的食物称重记录，间隔 2-3 个月。在这些男性和女性中，有 51 人在每次结束时提供了空腹血样。此外，18 名参与者在第一次和第二次连续 3 天分别提供了 3 个空腹样本和 3 个非空腹样本。两次之间的饮食和血液变量没有差异。非空腹血浆总 AR 浓度 [210 nmol/L (95% CI: 140, 314)) 高于空腹 [99 nmol/L (95% CI: 72, 137)] (P < 0.0001)。平均 WG 摄入量为 70 +/- 61 g/d（41% 来自黑麦），总 WG 摄入量的组内相关系数为 0.44（95% CI：0.26，0.63），空腹血浆总 AR 浓度为 0.47（95% CI：0.27，0.67），表明重现性中等。当使用两种情况的平均值时，空腹血浆总 AR 与 WG 黑麦 + 小麦（r(s) = 0.53；P < 0.001）和谷物纤维摄入量（r(s) = 0.32；P < 0.05）呈中度相关。这表明空腹样本中的血浆 AR 浓度可以用作具有高且一致的 WG 摄入量的自由生活人群中黑麦 + 小麦 WG 摄入量的生物标志物。 J.努特尔。 141：1712-1718，2011。
Plasma alkylresorcinols (AR) are useful as dietary biomarkers of wheat and rye whole grain (WG) during interventions but need to be validated in free-living populations. This study estimated the medium-term reproducibility and relative validity of plasma AR as biomarkers of WG and cereal fiber intake. Seventy-two Swedish adults kept 3-d weighed food records on 2 occasions 2-3 mo apart. Of these men and women, 51 provided a fasting blood sample at the end of each occasion. In addition, 18 participants provided 3 fasting and 3 nonfasting samples for 3 consecutive days on the first and second occasions, respectively. Dietary and blood variables did not differ between the 2 occasions. Nonfasting plasma total AR concentration [210 nmol/L (95% CI: 140, 314)) was higher than fasting [99 nmol/L (95% CI: 72, 137)] (P < 0.0001). Mean WG intake was 70 +/- 61 g/d (41% from rye) and the intra-class correlation coefficient was 0.44 (95% CI: 0.26, 0.63) for total WG intake and 0.47 (95% CI: 0.27, 0.67) for the fasting plasma total AR concentration, suggesting moderate reproducibility. Fasting plasma total AR moderately correlated with WG rye + wheat (r(s) = 0.53; P < 0.001) and cereal fiber intake (r(s) = 0.32; P < 0.05) when using mean values from both occasions. This suggests that plasma AR concentration in fasting samples can be used as a biomarker of rye + wheat WG intake in free-living populations with a high and consistent WG intake. J. Nutr. 141: 1712-1718, 2011.