Brain connectivity in non-reading impaired children and children diagnosed with developmental dyslexia
Brain connectivity in non-reading impaired children and children diagnosed with developmental dyslexia
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DOI：
10.1016/j.neuropsychologia.2009.03.009
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发表时间：
2009-07-01
期刊：
影响因子：
2.6
通讯作者：
Black, Jeffrey
中科院分区：
文献类型：
--
作者：
Odegard, Timothy N.;Farris, Emily A.;Black, Jeffrey
应用扩散张量成像（DTI）技术研究阅读障碍儿童和非阅读障碍儿童白色物质与阅读能力的关系。17名儿童（7名无阅读障碍，10名阅读障碍）参加了这项研究。DTI以2 mm各向同性分辨率进行，沿沿着30个非共线方向覆盖全脑。通过基于道的空间统计（TBSS）处理的数据进行体素分析。这些数据重复了以前在多项研究中看到的结果，并扩展了研究结果，包括真实的词和伪词解码的测量。在左后胼胝体中观察到分数各向异性（FA）值和解码的两种措施之间的负相关。在左侧上级放射冠中观察到FA值与真实的词和伪词解码之间的正相关。辐射冠和阅读技能之间的相关性的研究结果的扩展为未来阅读的神经学基础的研究提出了一个重要的方向。(C)2009爱思唯尔有限公司保留所有权利。
Diffusion Tensor Imaging (DTI) was used to investigate the relationship between white matter and reading abilities in reading impaired and non-reading impaired children. Seventeen children (7 non-reading impaired, 10 reading impaired) participated in this study. DTI was performed with 2 mm isotropic resolution to cover the entire brain along 30 noncollinear directions. Voxelwise analyses were conducted on data processed through Tract Based Spatial Statistics (TBSS). The data replicated previous results seen across multiple studies and extended findings to include measures of both real word and pseudoword decoding. Negative correlations were observed in the left posterior corpus callosum between fractional anisotropy (FA) values and both measures of decoding. Positive correlations between FA values and real word and pseudoword decoding were observed in the left superior corona radiata. This extension of findings regarding correlations between the corona radiata and reading skills suggests an important direction for future research into the neurological substrates of reading. (C) 2009 Elsevier Ltd. All rights reserved.