Ag2S quantum dot: a bright and biocompatible fluorescent nanoprobe in the second near-infrared window.
Ag2S quantum dot: a bright and biocompatible fluorescent nanoprobe in the second near-infrared window.
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Ag2S 量子点:第二个近红外窗口中的明亮且生物相容性荧光纳米探针。
DOI:
10.1021/nn301218z
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发表时间:
2012-05-22
期刊:
影响因子:
17.1
通讯作者:
Wang Q
中科院分区:
文献类型:
--
作者:
Zhang Y;Hong G;Zhang Y;Chen G;Li F;Dai H;Wang Q
Ag2S quantum dots (QDs) emitting in the second near-infrared region (NIR-II, 1.0~1.4 μm) are demonstrated as a promising fluorescent probe with both bright photoluminescence and high biocompatibility for the first time. Highly selective in vitro targeting and imaging of different cell lines are achieved using biocompatible NIR-II Ag2S QDs with different targeting ligands. The cytotoxicity study illustrates the Ag2S QDs with negligible effects in altering cell proliferation, triggering apoptosis and necrosis, generating reactive oxygen species (ROS), and causing DNA damage. Our results have opened up the possibilities of using these biocompatible Ag2S QDs for in vivo anatomical imaging and early-stage tumor diagnosis with deep tissue penetration, high sensitivity, as well as elevated spatial and temporal resolution owing to their high emission efficiency in the unique NIR-II imaging window.
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