Regional homogeneity abnormalities in patients with transient ischaemic attack: A resting-state fMRI study
Regional homogeneity abnormalities in patients with transient ischaemic attack: A resting-state fMRI study
复制标题
短暂性脑缺血发作患者的区域同质性异常：静息态功能磁共振成像研究
DOI：
10.1016/j.clinph.2013.08.010
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发表时间：
2014-03-01
影响因子：
4.7
通讯作者：
He, Li
中科院分区：
文献类型：
--
作者：
Guo, Jian;Chen, Ning;He, Li
目的：探讨短暂性脑缺血发作（TIA）患者静息状态下的局部活动异常，并结合功能磁共振成像（fMRI）检查局部活动异常与临床变量的关系。方法：对21例右侧TIA患者和21例健康志愿者进行静息状态fMRI检查。结果：TIA患者右侧背外侧前额叶皮层（dlPFC）、右侧下前额叶皮层（iPFC）、右侧腹侧前扣带皮层（vACC）和右侧背侧后扣带皮层（dPCC）的ReHo均低于对照组。此外，平均ReHo值在右侧dlPFC和右侧iPFC与蒙特利尔认知评估（莫卡）在TIA patients.Conclusions：TIA患者在静息状态下的神经活动的变化，即使没有明显的缺血性病变在常规MRI。ReHo的静息态功能磁共振成像和认知之间的正相关性表明，ReHo可能是一个很有前途的工具，以观察TIA的神经生物学后果。意义：本研究揭示了异常的局部同步自发神经活动的TIA患者。(C)2013年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To investigate regional activity abnormalities in the resting state in patients with transient ischaemic attack (TIA) using a regional homogeneity (ReHo) method combined with functional magnetic resonance imaging (fMRI) and to examine the relationship between regional activity abnormalities and clinical variables.Methods: Resting-state fMRI was conducted in 21 patients with right-sided TIA and in 21 healthy volunteers. The ReHo was calculated to assess the strength of the local signal synchrony and was compared between the two groups.Results: Compared with the controls, the TIA patients exhibited a decreased ReHo in the right dorsolateral prefrontal cortex (dlPFC), the right inferior prefrontal cortex (iPFC), the right ventral anterior cingulate cortex (vACC) and the right dorsal posterior cingulate cortex (dPCC). In addition, the mean ReHo values in the right dlPFC and the right iPFC were significantly correlated with the Montreal Cognitive Assessment (MoCA) in TIA patients.Conclusions: Neural activities in the resting state are changed in TIA patients even without visible ischaemic lesions on conventional MRI. The positive correlation between the ReHo of resting-state fMRI and cognition suggests that ReHo could be a promising tool to observe the neurobiological consequences of TIA.Significance: The present study revealed abnormal local synchronisation of spontaneous neural activities in patients with TIA. (C) 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.