RETINOID X-RECEPTOR INTERACTS WITH NUCLEAR RECEPTORS IN RETINOIC ACID, THYROID-HORMONE AND VITAMIN-D3 SIGNALING
RETINOID X-RECEPTOR INTERACTS WITH NUCLEAR RECEPTORS IN RETINOIC ACID, THYROID-HORMONE AND VITAMIN-D3 SIGNALING
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DOI：
10.1038/355446a0
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发表时间：
1992-01-30
期刊：
影响因子：
64.8
通讯作者：
EVANS, RM
中科院分区：
文献类型：
--
作者：
KLIEWER, SA;UMESONO, K;EVANS, RM
细胞对维甲酸及其代谢物的反应是通过两个结构和药理学上不同的受体家族来实现的：维甲酸受体（RAR） 2,3和类维甲酸X受体（RXR） 1。在这里，我们报道了RAR和RXR的转录活性可以通过两种蛋白之间的直接相互作用相互调节。RAR和RXR在结合靶DNA方面具有高度的协同性，这与之前的报道一致，表明RAR或RXR与其同源反应元件的结合被核提取物中存在的因子所增强4,5。RXR还与核受体直接相互作用并增强其结合，从而对维生素D3和甲状腺激素T3产生反应；这些受体的dna结合活性也受到核提取物6-9的刺激。综上所述，这些数据表明RXR在多种激素信号通路中起核心作用。
CELLULAR responsiveness to retinoic acid and its metabolites is conferred through two structurally and pharmacologically distinct 1 families of receptors: the retinoic acid receptors (RAR) 2,3 and the retinoid X receptors (RXR) 1. Here we report that the transcriptional activity of RAR and RXR can be reciprocally modulated by direct interactions between the two proteins. RAR and RXR have a high degree of cooperativity in binding to target DNA, consistent with previous reports indicating that the binding of either RAR or RXR to their cognate response elements is enhanced by factors present in nuclear extracts 4,5. RXR also interacts directly with and enhances the binding of nuclear receptors conferring responsiveness to vitamin D3 and thyroid hormone T3; the DNA-binding activities of these receptors are also stimulated by the presence of nuclear extracts 6-9. Together these data indicate that RXR has a central role in multiple hormonal signalling pathways.