Process of fertilization in the human and its abnormalities: diagnostic and therapeutic possibilities.
Process of fertilization in the human and its abnormalities: diagnostic and therapeutic possibilities.
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人类受精过程及其异常：诊断和治疗的可能性。
DOI：
10.1097/00006254-199408000-00025
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发表时间：
1994
影响因子：
6.2
通讯作者：
A. Acosta
中科院分区：
文献类型：
--
作者：
A. Acosta
受精是配子相互作用中一系列复杂的分子协调事件，从配子识别开始，到第一次卵裂分裂结束，在时间上是一个相对较短的过程。了解这一过程与临床医生有关，因为对其步骤的评价可能会定义受精失败的水平并允许采取纠正措施，可以帮助设计证明不同受精停滞模式的测试，并可以允许在配子相互作用水平上用避孕方法干扰该过程。人类的自然过程几乎是未知的，必须使用体外环境中的事件来理解体内过程。受精包括配子的融合和卵母细胞的激活，并建立一个新个体的基因型（1）。对于正常的过程发生，配子通常应该经历增殖，染色体交换和减数分裂，分化，成熟和运输的减少的复杂过程，以结束在精子和卵母细胞中首先发生的不同膜融合步骤。其次是不同水平的配子相互作用，直至卵裂发生。融合过程可能发生在未完全成熟的精子和卵母细胞之间：仅穿透就完成了，而没有正常的后续步骤发生（2）。
Fertilization, chronologically a relatively short process, is a complex sequence of coordinated molecular events in gamete interaction starting at gamete recognition and terminating at first cleavage division. Understanding this process is relevant to clinicians, because evaluation of its steps may define the levels at which fertilization can fail and allow corrective measures, can help to design tests demonstrating different modalities of fertilization arrest, and can allow to interfere with the process with contraception methods at the gamete interaction level. The human natural process is almost unknown, and events in the in vitro setting have to be used to understand the in vivo process. Fertilization involves the fusion of the gametes with activation of the oocyte and establishes the genotype of a new individual (l). For a normal process to occur, the gametes should have normally undergone a complex process of proliferation, chromosomal exchange and reduction at meiosis, differentiation, maturation and transport, to end up in the different membrane fusion steps that occur in the sperm and the oocyte first. and at different levels of gamete interaction sec-ondly, until cleavage division occurs. Fusion processes may happen between not fully mature sperm and oocytes: penetration alone is accomplished without the normal subsequent steps occurring (2).