Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease
Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease
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DOI：
10.1097/wnn.0b013e318145a6f6
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发表时间：
2007-09-01
影响因子：
1.4
通讯作者：
Eidelberg, David
中科院分区：
文献类型：
--
作者：
Zgaljardic, Dennsis J.;Borod, Joan C.;Eidelberg, David
目的：冷漠的患病率进行了评估，在选择的认知和精神病学变量在32名非痴呆患者帕金森病（PD）和29人口统计学匹配的健康对照participator. Background：冷漠是常见的PD，虽然区分冷漠的运动，认知，和/或其他神经精神症状可能是具有挑战性的。以往的研究报道了情感淡漠与认知功能障碍，特别是执行功能障碍之间的正相关。严格的标准被用来排除痴呆患者。结果：约44%的患者赞同显着水平的冷漠。这些患者的表现比患者的冷漠水平不显着选择措施的语言流畅性和语言和非语言概念化的措施。此外，他们报告了更多的抑郁和行为障碍相关的症状比那些没有显着水平的冷漠的患者。冷漠与抑郁自评和执行功能障碍显著相关。认知任务评估语言流畅性，工作记忆，口头抽象和自我报告的执行功能障碍的措施表现出显着的预测增加的水平apathy.Conclusions：我们的研究结果表明，冷漠的非痴呆患者PD似乎与执行功能障碍密切相关。
Objective: The prevalence of apathy was assessed across select cognitive and psychiatric variables in 32 nondemented patients with Parkinson disease (PD) and 29 demographically matched healthy control participants.Back-ground: Apathy is common in PD, although differentiating apathy from motor, cognitive, and/or other neuropsychiatric symptoms can be challenging. Previous studies have reported a positive relationship between apathy and cognitive impairment, particularly executive dysfunction.Method: Patients were categorized according to apathy symptom severity. Stringent criteria were used to exclude patients with dementia.Results: Approximately 44% of patients endorsed significant levels of apathy. Those patients performed worse than patients with nonsignificant levels of apathy on select measures of verbal fluency and on a measure of verbal and nonverbal conceptualization. Further, they reported a greater number of symptoms related to depression and behavioral disturbance than did those patients with nonsignificant levels of apathy. Apathy was significantly related to self-report of depression and executive dysfunction. Performance on cognitive tasks assessing verbal fluency, working memory, and verbal abstraction and also on a self-report measure of executive dysfunction was shown to significantly predict increasing levels of apathy.Conclusions: Our findings suggest that apathy in nondemented patients with PD seems to be strongly associated with executive dysfunction.