Structure and function of the ULK1 complex in autophagy.
Structure and function of the ULK1 complex in autophagy.
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DOI：
10.1016/j.ceb.2016.02.010
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发表时间：
2016-04
影响因子：
7.5
通讯作者：
Hurley JH
中科院分区：
文献类型：
--
作者：
Lin MG;Hurley JH
ULK1复合物启动自噬体形成，将细胞营养状态与自噬中的下游事件联系起来。最近的研究表明，ULK1复合物也可能在选择性自噬中被激活，而不依赖于营养或能量状态。在这篇综述中，我们将讨论我们目前对ULK1复合物如何受不同信号调节的理解，以及这种复合物如何调节自噬机制的其他组成部分。最近获得的结构数据都ULK1和orthophosphorus酵母Atg1复合物开始阐明更高层次的组织ULK1复合物。最终，这些见解可能使人们有可能了解货物组织和结构如何在选择性自噬启动中招募和调节ULK1。
The ULK1 complex initiates autophagosome formation, linking cellular nutrient status to downstream events in autophagy. Recent work suggests that the ULK1 complex might also be activated in selective autophagy independent of nutrient or energy status. In this review we will discuss our current understanding of how the ULK1 complex is regulated by different signals, as well as how this complex then regulates other components of the autophagy machinery. Recently obtained structural data both on ULK1 and the orthologous yeast Atg1 complex are beginning to shed light on the higher-order organization of ULK1 complex. Ultimately, these insights might make it possible to understand how cargo organization and structure recruits and regulates ULK1 in selective autophagy initiation.