Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature
Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature
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DOI：
10.3892/ol.2014.2731
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发表时间：
2015-02-01
期刊：
影响因子：
2.9
通讯作者：
Mimata, Hiromitsu
中科院分区：
文献类型：
--
作者：
Shibuya, Tadamasa;Mori, Kenichi;Mimata, Hiromitsu
摘要本研究报告一罕见的前列腺原始神经外胚层肿瘤。一名23岁男性因排尿困难和肛门疼痛到大分医疗中心（日本大分）就诊。通过计算机断层扫描和磁共振成像确定了前列腺中的大肿块和盆腔区域中的一些肿胀淋巴结。因此，患者被大分大学医院（日本由府）收治，在那里进行了前列腺活检。组织学分析显示小圆形细胞MIC-2表达阳性，荧光原位杂交分析检测到染色体22 q12处涉及尤文肉瘤断裂点区域1的易位。因此，建立了前列腺PNET的诊断。全身化疗是首选的治疗方法，但疗效不佳。患者在症状首次发作后约4个月死亡。全世界报告了8例前列腺PNET;相比之下，本病例的结局最不令人满意。
The present study reports a rare case of primitive neuroectodermal tumor (PNET) of the prostate. A 23-year-old male presented to Oita Medical Center (Oita, Japan) with the complaint of dysuria and anal pain. A large mass in the prostate and a number of swollen lymph nodes in the pelvic region were identified by a computed tomography scan and magnetic resonance imaging. The patient was, thus, admitted to Oita University Hospital (Yufu, Japan), where a biopsy of the prostate gland was performed. Histological analysis revealed small round cells that were positive for MIC-2 expression and fluorescent in situ hybridization analysis detected a translocation involving Ewing sarcoma breakpoint region 1 at chromosome 22q12. Thus, a diagnosis of PNET of the prostate was established. Systemic chemotherapy was the selected treatment, however, a poor response was obtained. The patient succumbed approximately four months after the initial onset of symptoms. PNET of the prostate has been reported in eight cases worldwide; in comparison, the present case exhibited the most unsatisfactory outcome.