Trends in Risk-Adjusted 28-Day Mortality Rates for Patients Hospitalized with COVID-19 in England
Trends in Risk-Adjusted 28-Day Mortality Rates for Patients Hospitalized with COVID-19 in England
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DOI：
10.12788/jhm.3599
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发表时间：
2021-05-01
影响因子：
2.6
通讯作者：
Horwitz, Leora, I
中科院分区：
文献类型：
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作者：
Jones, Simon;Mason, Neil;Horwitz, Leora, I
早期报告显示，2019冠状病毒病（COVID-19）的死亡率很高。死亡率最近有所降低;然而，患者现在也更年轻，合并症更少。我们探索了英格兰5个月内因COVID-19住院患者的28天死亡率，并对一系列潜在的缓解变量进行了调整，包括社会人口统计学和合并症。在102，610例住院治疗中，粗死亡率从2020年3月的33.4%（95%CI，32.9-34.0）下降至7月的15.5%（95%CI，14.1-17.0）。调整后的死亡率从3月份的33.4%（95%CI，32.8-34.1）下降到7月份的17.4%（95%CI，11.3-26.9）。死亡的相对危险度从3月的参考值1下降到7月的0.52（95%CI，0.34-0.80）。这表明死亡率的下降不仅仅是由于COVID-19患者的人口统计数据发生变化。(C)2021医院医学学会
Early reports showed high mortality from coronavirus disease 2019 (COVID-19). Mortality rates have recently been lower; however, patients are also now younger, with fewer comorbidities. We explored 28-day mortality for patients hospitalized for COVID-19 in England over a 5-month period, adjusting for a range of potentially mitigating variables, including sociodemographics and comorbidities. Among 102,610 hospitalizations, crude mortality decreased from 33.4% (95% CI, 32.9-34.0) in March 2020 to 15.5% (95% CI, 14.1-17.0) in July. Adjusted mortality decreased from 33.4% (95% CI, 32.8-34.1) in March to 17.4% (95% CI, 11.3-26.9) in July. The relative risk of mortality decreased from a reference of 1 in March to 0.52 (95% CI, 0.34-0.80) in July. This demonstrates that the reduction in mortality is not solely due to changes in the demographics of those with COVID-19. (C) 2021 Society of Hospital Medicine