US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis.
US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis.
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DOI：
10.1136/thoraxjnl-2015-207360
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发表时间：
2016-01
期刊：
影响因子：
10
通讯作者：
US Cystic Fibrosis Foundation and European Cystic Fibrosis Society
中科院分区：
文献类型：
--
作者：
Floto RA;Olivier KN;Saiman L;Daley CL;Herrmann JL;Nick JA;Noone PG;Bilton D;Corris P;Gibson RL;Hempstead SE;Koetz K;Sabadosa KA;Sermet-Gaudelus I;Smyth AR;van Ingen J;Wallace RJ;Winthrop KL;Marshall BC;Haworth CS;US Cystic Fibrosis Foundation and European Cystic Fibrosis Society
非结核分枝杆菌 (NTM) 是普遍存在的环境微生物，可引起慢性肺部感染，特别是对于已患有囊性纤维化 (CF) 等炎症性肺病的个体。 NTM 引起的肺部疾病已成为 CF 患者健康的主要威胁，但诊断困难且治疗困难。为了应对这一挑战，美国囊性纤维化基金会 (CFF) 和欧洲囊性纤维化协会 (ECFS) 召集了一个专家小组，为 CF 患者的 NTM 肺部疾病的筛查、调查、诊断和管理制定共识建议。十九位专家受邀参与建议制定过程。采用人口、干预、比较、结果（PICO）方法和系统文献综述来为建议草案提供信息。委员会采用匿名投票程序来达成共识。所有委员会成员都被要求对每项陈述进行评分：0 分，完全不同意，9 分，完全同意； 80% 或更多的分数在 7 到 9 之间被认为是“良好”一致性。此外，委员会还征求了美国和欧洲 CF 社区的反馈意见，并在制定最终推荐声明时考虑了这些反馈意见。每项推荐声明均进行三轮投票，获得80%的共识。通过这一过程，我们针对 CF 个体 NTM 感染的筛查、调查、诊断和治疗提出了一系列务实的、基于证据的建议，作为优化这种具有挑战性的疾病管理的第一步。
Non-tuberculous mycobacteria (NTM) are ubiquitous environmental organisms that can cause chronic pulmonary infection, particularly in individuals with pre-existing inflammatory lung disease such as cystic fibrosis (CF). Pulmonary disease caused by NTM has emerged as a major threat to the health of individuals with CF but remains difficult to diagnose and problematic to treat. In response to this challenge, the US Cystic Fibrosis Foundation (CFF) and the European Cystic Fibrosis Society (ECFS) convened an expert panel of specialists to develop consensus recommendations for the screening, investigation, diagnosis and management of NTM pulmonary disease in individuals with CF. Nineteen experts were invited to participate in the recommendation development process. Population, Intervention, Comparison, Outcome (PICO) methodology and systematic literature reviews were employed to inform draft recommendations. An anonymous voting process was used by the committee to reach consensus. All committee members were asked to rate each statement on a scale of: 0, completely disagree, to 9, completely agree; with 80% or more of scores between 7 and 9 being considered ‘good’ agreement. Additionally, the committee solicited feedback from the CF communities in the USA and Europe and considered the feedback in the development of the final recommendation statements. Three rounds of voting were conducted to achieve 80% consensus for each recommendation statement. Through this process, we have generated a series of pragmatic, evidence-based recommendations for the screening, investigation, diagnosis and treatment of NTM infection in individuals with CF as an initial step in optimising management for this challenging condition.