Intrinsic and extrinsic factors in skin ageing: A review
Intrinsic and extrinsic factors in skin ageing: A review
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DOI：
10.1111/j.1468-2494.2007.00415.x
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发表时间：
2008-04-01
影响因子：
2.3
通讯作者：
Maibach, H. I.
中科院分区：
文献类型：
--
作者：
Farage, M. A.;Miller, K. W.;Maibach, H. I.
随着工业化国家中老龄人口的比例持续增加，老年人的皮肤病学问题在医学上的重要性也在增长。内在的结构变化是衰老的自然结果，由遗传决定。老化的速度在不同的人群之间，以及在不同的解剖部位之间，甚至在同一个人内部，都有很大的不同。任何个体皮肤老化的内在速率也会受到个人和环境因素的显著影响，特别是暴露于紫外线的量。光损伤大大加速了皮肤的可见老化，也大大增加了皮肤肿瘤的风险。随着人口老龄化，皮肤病学的重点必须从改善皮肤老化的美容后果转移到减少与老化皮肤问题相关的真正发病率。更好地了解皮肤老化的内在和外在影响，以及区分皮肤老化的可伸缩方面（主要是激素和生活方式的影响）与不可伸缩方面（主要是内在老化），对这一努力至关重要。
As the proportion of the ageing population in industrialized countries continues to increase, the dermatological concerns of the aged grow in medical importance. Intrinsic structural changes occur as a natural consequence of ageing and are genetically determined. The rate of ageing is significantly different among different populations, as well as among different anatomical sites even within a single individual. The intrinsic rate of skin ageing in any individual can also be dramatically influenced by personal and environmental factors, particularly the amount of exposure to ultraviolet light. Photodamage, which considerably accelerates the visible ageing of skin, also greatly increases the risk of cutaneous neoplasms. As the population ages, dermatological focus must shift from ameliorating the cosmetic consequences of skin ageing to decreasing the genuine morbidity associated with problems of the ageing skin. A better understanding of both the intrinsic and extrinsic influences on the ageing of the skin, as well as distinguishing the retractable aspects of cutaneous ageing (primarily hormonal and lifestyle influences) from the irretractable (primarily intrinsic ageing), is crucial to this endeavour.