Hypothalamic leptin regulation of energy homeostasis and glucose metabolism
Hypothalamic leptin regulation of energy homeostasis and glucose metabolism
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DOI：
10.1113/jphysiol.2007.135590
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发表时间：
2007-09-01
影响因子：
5.5
通讯作者：
Morton, Gregory J.
中科院分区：
文献类型：
--
作者：
Morton, Gregory J.
越来越多的证据表明，食物摄入、能量消耗和内源性葡萄糖产生受到下丘脑区域的调节，这些区域对各种外周信号做出反应。因此，响应于能量储存或循环营养物的减少，大脑启动响应以促进正能量平衡，以恢复和维持能量和葡萄糖稳态。相反，在营养丰富和能量储存过剩的时候，关键的下丘脑区域激活反应，以促进负能量平衡（即减少食物摄入和增加能量消耗）和减少营养可用性（减少内源性葡萄糖产生）。因此，对来自这些激素或营养相关信号的传入输入的受损反应或“抵抗”将被预测为有利于体重增加和胰岛素抵抗，并且可能有助于肥胖和2型糖尿病的发展。
Growing evidence suggests that food intake, energy expenditure and endogenous glucose production are regulated by hypothalamic areas that respond to a variety of peripheral signals. Therefore, in response to a reduction in energy stores or circulating nutrients, the brain initiates responses in order to promote positive energy balance to restore and maintain energy and glucose homeostasis. In contrast, in times of nutrient abundance and excess energy storage, key hypothalamic areas activate responses to promote negative energy balance (i.e. reduced food intake and increased energy expenditure) and decreased nutrient availability (reduced endogenous glucose production). Accordingly, impaired responses or 'resistance' to afferent input from these hormonal or nutrient-related signals would be predicted to favour weight gain and insulin resistance and may contribute to the development of obesity and type 2 diabetes.