Assessment of peripheral neuropathy using measurement of the current perception threshold with the Neurometer® in patients with type 2 diabetes mellitus
Assessment of peripheral neuropathy using measurement of the current perception threshold with the Neurometer® in patients with type 2 diabetes mellitus
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DOI：
10.1177/147323000503300410
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发表时间：
2005-07-01
影响因子：
1.6
通讯作者：
Aso, Y
中科院分区：
文献类型：
--
作者：
Matsutomo, R;Takebayashi, K;Aso, Y
使用Neurosurgery（R）在2000、250和5Hz下测量电流感知阈值（CPT）评估三种不同神经纤维类型的功能。应用该方法对116例2型糖尿病患者和38例健康对照者的周围神经病变进行了研究。糖尿病患者2000 Hz的CPT显著高于对照组，并与运动和感觉神经传导速度呈显著负相关。在250 Hz时，CPT与振动觉阈值呈显著正相关。在5 Hz时，Schellong试验中感觉减退患者的收缩压变化往往小于感觉正常或感觉过敏的患者。增生性糖尿病视网膜病变和大量白蛋白尿患者CPT值显著升高。这些数据表明，CPT是有用的检测异常的有髓神经纤维，而不是无髓神经纤维在2型糖尿病患者。
Measurement of current perception threshold (CPT) using the Neuromete (R) at 2000, 250 and 5 Hz assesses function in three different nerve fibre types. This method was used to investigate peripheral neuropathy in 116 patients with type 2 diabetes mellitus and 38 healthy controls. The CPT at 2000 Hz was significantly higher in diabetic patients than in controls, and showed a significant negative correlation with motor and sensory nerve conduction velocities. At 250 Hz, CPT showed a significant positive correlation with the vibration perception threshold. At 5 Hz, the change in systolic blood pressure in the Schellong test in patients with hypoaesthesia tended to be less than in those with normal sensation or hyperaesthesia. Significantly higher CPT values were obtained in patients with proliferative diabetic retinopathy and macroalbuminuria. These data suggest that CPT is useful in detecting abnormalities of myelinated as opposed to unmyelinated nerve fibres in patients with type 2 diabetes.