Melanotic oncocytic metaplasia of the nasopharynx: a report of seven cases and review of the literature
Melanotic oncocytic metaplasia of the nasopharynx: a report of seven cases and review of the literature
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DOI：
10.1007/s00428-003-0970-4
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发表时间：
2004-04-01
期刊：
影响因子：
3.5
通讯作者：
Sano, T
中科院分区：
文献类型：
--
作者：
Sakaki, M;Shek, TWH;Sano, T
我们描述了7例黑色素嗜酸细胞化生的鼻咽和审查其他五例文献。它通常是一个小的，棕色到黑色的病变，发生在耳咽管开口周围，那里有丰富的浆液粘液腺和淋巴组织。有时可见多发或双侧病变。所有12例报告病例均来自亚洲。黑色素嗜酸细胞化生主要发生在男性（男性：女性=11：1），平均年龄为68岁。简单的切除活检似乎是治愈性的。显微镜下，黑色素性嗜酸细胞化生是腺体上皮的嗜酸细胞化生和细胞质中黑色素沉着的结合。Fontana-Masson染色和S-100蛋白免疫组化染色显示，腺体和间质中有大量黑素细胞，并有明显的树突，这些黑素细胞可能将黑素转移到邻近的腺体。黑色素性嗜酸细胞化生的确切发病机制尚不清楚，但我们假设该病变可能与耳咽管周围浆液粘液腺的嗜酸细胞化生有关，随后在某些神经肽的影响下局部产生和/或获得黑色素。附近。认识黑素性嗜酸细胞化生具有重要的临床意义，因为它可能被误诊为恶性肿瘤。
We describe seven cases of melanotic oncocytic metaplasia of the nasopharynx and review five other cases in the literature. It is usually a small, brown to black lesion that occurs around the Eustachian tube opening, where abundant seromucinous glands and lymphoid tissue are present. Multiple or bilateral lesions are sometimes seen. All 12 reported cases are of Asian origin. Melanotic oncocytic metaplasia occurs predominantly in men (male:female=11:1), with a mean age of 68 years. Simple excisional biopsy appears to be curative. Microscopically, melanotic oncocytic metaplasia is a combination of oncocytic metaplasia of the epithelium of the gland and melanin pigmentation in its cytoplasm. Fontana-Masson staining and immunohistochemical staining of S-100 protein revealed numerous melanocytes with conspicuous dendrites in the glands and stroma, which probably transfer melanin to adjacent glands. The exact pathogenesis of melanotic oncocytic metaplasia is unknown, but we postulate that the lesion could be related to the oncocytic metaplasia of the seromucinous glands around the Eustachian tube, which is followed by the local production and/or acquisition of the melanin pigment, under the influence of certain neuropeptides in the vicinity. The recognition of melanotic oncocytic metaplasia is of clinical importance, as it may be misdiagnosed as a malignancy to the unwary.