Biological actions of silver nanoparticles embedded in titanium controlled by micro-galvanic effects
Biological actions of silver nanoparticles embedded in titanium controlled by micro-galvanic effects
复制标题
微电偶效应控制嵌入钛中的银纳米粒子的生物作用
DOI：
10.1016/j.biomaterials.2010.09.066
复制
发表时间：
2011-01-01
期刊：
影响因子：
14
通讯作者：
Chu, Paul K.
中科院分区：
文献类型：
--
作者：
Cao, Huiliang;Liu, Xuanyong;Chu, Paul K.
利用单步银等离子体浸没离子注入（Ag-PIII）嵌入有银纳米颗粒（Ag NPs）的钛显示出微电流效应，其产生受控的抗菌活性和与成骨细胞的优异相容性。扫描电子显微镜（SEM）显示，在经历Ag-PIII之后，在钛表面上均匀地形成平均尺寸约为5 nm和8 nm的纳米颗粒。透射电子显微镜（TEM）和X射线光电子能谱（XPS）分析表明，这些纳米颗粒是由α-Ti（Ag）固溶体通过局部成核过程在钛表面和钛表面下生成的金属银。Ag-PIII样品抑制金黄色葡萄球菌和大肠杆菌的生长，同时促进成骨细胞的增殖。电化学极化和Zeta电位测试结果表明，Ag纳米粒子的低表面毒性和良好的细胞相容性与其与钛基体之间的微电流效应有关。银纳米颗粒的化学性质在控制细胞毒性方面很重要，这项研究为设计纳米结构表面打开了一个新的窗口，Ag纳米粒子可以准确地定制（C）2010 Elsevier Ltd保留所有权利
Titanium embedded with silver nanoparticles (Ag NPs) using a single step silver plasma immersion ion implantation (Ag-PIII) demonstrate micro-galvanic effects that give rise to both controlled antibacterial activity and excellent compatibility with osteoblasts Scanning electron microscopy (SEM) shows that nanoparticles with average sizes of about 5 nm and 8 nm are formed homogeneously on the titanium surface after undergoing Ag-PIII for 05 h and 1 h respectively Transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) indicate that those nanoparticles are metallic silver produced on and underneath the titanium surface via a local nucleation process from the solid solution of alpha-Ti(Ag) The Ag-PIII samples inhibit the growth of both Staphylococcus aureus and Escherichia cob while enhancing proliferation of the osteoblast-like cell line MG63 Electrochemical polarization and Zeta potential measurements demonstrate that the low surface toxicity and good cytocompatibility are related to the micro-galvanic effect between the Ag NPs and titanium matrix Our results show that the physico-chemical properties of the Ag NPs are important in the control of the cytotoxicity and this study opens a new window for the design of nanostructured surfaces on which the biological actions of the Ag NPs can be accurately tailored (C) 2010 Elsevier Ltd All rights reserved