Lipid Peroxidation Is Associated with the Severity of Periodontal Disease and Local Inflammatory Markers in Patients with Type 2 Diabetes
Lipid Peroxidation Is Associated with the Severity of Periodontal Disease and Local Inflammatory Markers in Patients with Type 2 Diabetes
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DOI：
10.1210/jc.2011-3397
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发表时间：
2012-08-01
影响因子：
5.8
通讯作者：
Orrico, Silvana R. P.
中科院分区：
文献类型：
--
作者：
Bastos, Alliny S.;Graves, Dana T.;Orrico, Silvana R. P.
背景：牙周炎是最常见的骨溶解性疾病，被公认为糖尿病的常见并发症。糖尿病患者体内脂质过氧化(LPO)升高，可能与炎症反应的调节有关。LPO在糖尿病和牙周病患者中的水平尚未得到评估。目的：本研究的目的是评估2型糖尿病和非糖尿病患者的LPO水平及其与牙周状况和炎性细胞因子的相关性。设计和背景：这是一项横断面研究，涉及圣保罗州立大学招收的巴西患者。患者：样本包括120名患者，根据糖尿病和血脂异常的状况分为四组：糖尿病控制不良的患者、控制良好的糖尿病患者和健康的个体。主要观察指标：对空腹血糖、糖化血红蛋白和血脂进行血液分析。进行牙周检查，采集龈沟液。通过检测氧化低密度脂蛋白(ELISA值)和丙二醛(HPLC值)评价LPO水平。结果：以丙二醛为指标的LPO在糖尿病组大鼠血浆和龈沟液中均明显升高。LPO标志物与牙周参数的显著相关性表明，LPO水平与炎症程度和炎症细胞因子的分泌有直接关系，尤其是在糖尿病患者。结论：LPO与糖尿病患者局部细菌炎症反应的严重程度和牙周疾病的易感性有重要关联。(J临床内分泌Metab 97：E1353-E1362,2012)
Context: Periodontitis is the most common lytic disease of bone and is recognized as a common complication of diabetes. Lipid peroxidation (LPO) is increased in diabetes and may be related to modulation of the inflammatory response. LPO levels in patients with diabetes and periodontal disease have not been evaluated.Objective: The aim of this study was to evaluate the levels of LPO and its correlation with periodontal status and inflammatory cytokines in type 2 diabetic and nondiabetic patients.Design and Setting: This is a cross-sectional study involving Brazilian patients recruited at the State University of Sao Paulo.Patients: The sample comprised 120 patients divided into four groups based upon diabetic and dyslipidemic status: poorly controlled diabetics with dyslipidemia, well-controlled diabetics with dyslipidemia, normoglycemic individuals with dyslipidemia, and healthy individuals.Main Outcome Measures: Blood analyses were carried out for fasting plasma glucose, glycated hemoglobin, and lipid profile. Periodontal examinations were performed, and gingival crevicular fluid was collected. LPO levels were evaluated by measuring oxidized low-density lipoprotein (ELISA) and malondialdehyde (HPLC). Cytokines were evaluated by the multiplex bead technique.Results: LPO evaluated by malondialdehyde in plasma and gingival crevicular fluid was significantly increased in diabetes groups. Significant correlations between LPO markers and periodontal parameters indicate a direct relationship between these levels and the severity of inflammation and secretion of inflammatory cytokines, particularly in diabetic patients.Conclusion: These findings suggest an important association for LPO with the severity of the local inflammatory response to bacteria and the susceptibility to periodontal disease in diabetic patients. (J Clin Endocrinol Metab 97: E1353-E1362, 2012)