Nature-derived materials for the fabrication of functional biodevices
Nature-derived materials for the fabrication of functional biodevices
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DOI：
10.1016/j.mtbio.2020.100065
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发表时间：
2020-06-01
影响因子：
8.2
通讯作者：
Yadavalli, V. K.
中科院分区：
文献类型：
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作者：
Pradhan, S.;Brooks, A. K.;Yadavalli, V. K.
大自然提供了令人难以置信的灵感来源，结构概念和材料，用于改善世界各地人们的生活，同时保护生态系统，解决环境可持续性问题。特别是，来自动物和植物来源的材料可以为这些应用提供低成本、可再生的结构单元。天然材料具有生物降解性、生物适应性、生物识别性、自我修复性和刺激响应性等特性。虽然长期用于组织工程和再生医学，但它们在功能设备中的使用，如（生物）电子，传感器和用于医疗保健和生物监测的光学系统，正受到越来越多的关注。本综述的目的是涵盖目前用于具有电气或电子行为的有源生物器械和组件的各种自然衍生和来源材料。我们讨论的材料范围从蛋白质和多肽，如丝和胶原蛋白，多糖，包括甲壳素和纤维素，海藻衍生的生物材料，和DNA。这些材料可以用作被动基底或支撑结构，并且通常作为功能元件本身或作为生物复合材料。我们进一步讨论了天然色素，如黑色素和靛蓝，作为设备中的活性元素。越来越多地，不同生物材料的组合被用于解决人类监测或医学中的制造和性能挑战。最后，本文综述了这些材料的来源、加工、降解和生物相容性。这一快速发展的多学科研究领域将通过系统地了解自然启发的材料和（生物）电子设备的设计概念来推进。
Nature provides an incredible source of inspiration, structural concepts, and materials toward applications to improve the lives of people around the world, while preserving ecosystems, and addressing environmental sustainability. In particular, materials derived from animal and plant sources can provide low-cost, renewable building blocks for such applications. Nature-derived materials are of interest for their properties of biodegradability, bioconformability, biorecognition, self-repair, and stimuli response. While long used in tissue engineering and regenerative medicine, their use in functional devices such as (bio)electronics, sensors, and optical systems for healthcare and biomonitoring is finding increasing attention. The objective of this review is to cover the varied nature derived and sourced materials currently used in active biodevices and components that possess electrical or electronic behavior. We discuss materials ranging from proteins and polypeptides such as silk and collagen, polysaccharides including chitin and cellulose, to seaweed derived biomaterials, and DNA. These materials may be used as passive substrates or support architectures and often, as the functional elements either by themselves or as biocomposites. We further discuss natural pigments such as melanin and indigo that serve as active elements in devices. Increasingly, combinations of different biomaterials are being used to address the challenges of fabrication and performance in human monitoring or medicine. Finally, this review gives perspectives on the sourcing, processing, degradation, and biocompatibility of these materials. This rapidly growing multidisciplinary area of research will be advanced by a systematic understanding of nature-inspired materials and design concepts in (bio) electronic devices.