Factors influencing mortality in acromegaly
Factors influencing mortality in acromegaly
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DOI：
10.1210/jc.2003-031199
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发表时间：
2004-02-01
影响因子：
5.8
通讯作者：
Gamble, GD
中科院分区：
文献类型：
--
作者：
Holdaway, IM;Rajasoorya, RC;Gamble, GD
对肢端肥大症的研究表明，与一般人群相比，肢端肥大症的死亡率增加了一倍。随着新的治疗方式的发展，确定与死亡率相关的预后因素变得重要。在1964年至2000年期间，208肢端肥大症患者在奥克兰医院进行了平均13年的随访。治疗方法为手术或放射性核素垂体植入术，除27例患者外，所有患者均接受垂体放疗。在研究期间，72名患者死亡，平均年龄为61 ± 12.8岁。那些死亡的人在诊断时年龄明显较大，高血压和糖尿病的患病率较高，更有可能患有垂体功能减退症。观察到的死亡率与预期死亡率之比（O/E比）从末次随访GH大于5 μ g/L的患者的2.6（95%置信区间，1.9-3.6）分别降至GH小于5、小于2和小于1 μ g/L的患者的2.5（1.6-3.8）、1.6（0.9-3）和1.1（0.5-2.1）（P
Studies of acromegaly have shown a doubling of mortality compared with the general population. With the development of new modalities of treatment, it has become important to identify prognostic factors relating to mortality. Between 1964 and 2000, 208 acromegalic patients were followed for a mean of 13 yr at Auckland Hospital. Treatment was by surgery or radionuclide pituitary implantation, and all except 27 patients received pituitary radiation. Over the duration of the study, 72 patients died at a mean age of 61+/-12.8 yr. Those dying were significantly older at diagnosis, had a higher prevalence of hypertension and diabetes, and were more likely to have hypopituitarism. The observed to expected mortality ratio (O/E ratio) fell from 2.6 (95% confidence interval, 1.9-3.6) in those with last follow-up GH greater than 5 mug/liter to 2.5 (1.6-3.8), 1.6 (0.9-3), and 1.1 (0.5-2.1) for those with GH less than 5, less than 2, and less than 1 mug/liter, respectively (P