PHASE RELATIONSHIP BETWEEN NORMAL HUMAN RESPIRATION AND BAROREFLEX RESPONSIVENESS
PHASE RELATIONSHIP BETWEEN NORMAL HUMAN RESPIRATION AND BAROREFLEX RESPONSIVENESS
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DOI：
10.1113/jphysiol.1980.sp013338
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发表时间：
1980-01-01
影响因子：
5.5
通讯作者：
ROBERTS, VL
中科院分区：
文献类型：
--
作者：
ECKBERG, DL;KIFLE, YT;ROBERTS, VL
研究了呼吸相位和呼吸频率对人体窦房结对动脉压力感受器刺激的反应的影响。在早期、中期和晚期吸气期间，或以通常呼吸频率呼气时，或者在早期吸气和呼气期间，以 3、6、12 和 24 次呼吸/分钟的呼吸频率时，通过短暂（0.6 s）、中等（30 mm Hg）颈部抽吸刺激颈动脉压力感受器。在吸气早期和中期以及呼气晚期施加压力感受器刺激仅引起轻微的窦房结抑制；在吸气晚期和呼气早期开始的刺激引起了最大的窦房结抑制。当呼吸频率为 3、6、12 次/分钟时，呼气压力反射反应明显大于吸气反应；在 24 次呼吸/分钟时，吸气和呼气压力感受器刺激产生了相当程度的窦房结抑制。在正常、安静的呼吸过程中，人类的压力感受反射反应会持续振荡。这是正常人重要的中枢生物节律。呼吸压力反射反应性的相移表明这种相互作用不能简单地归因于与中枢吸气神经元活动同步的门控。快速呼吸期间心率的规律化与吸气-呼气压力反射反应差异的丧失有关，这种反应在正常呼吸频率下存在。
Influences of respiration phase and breathing frequency on human sinus node responses to arterial baroreceptor stimulation were studied. Carotid baroreceptors were stimulated with brief (0.6 s), moderate (30 mm Hg) neck suction during early, mid and late inspiration, or expiration at usual breathing rates, or, during early inspiration and expiration at breathing rates of 3, 6, 12 and 24 breaths/min. Baroreceptor stimuli applied during early and mid inspiration and late expiration provoked only minor sinus node inhibition; stimuli begun during late inspiration and early expiration provoked maximum sinus node inhibition. At breathing rates of 3, 6, 12 breaths/min, expiratory baroreflex responses were significantly greater than inspiratory responses; at 24 breaths/min inspiratory and expiratory baroreceptor stimuli produced comparable degrees of sinus node inhibition. Human baroreflex responsiveness oscillates continuously during normal, quiet respiration. This is an important central biological rhythm in normal man. The phase shift of baroreflex reponsiveness on respiration suggests that this interaction cannot be ascribed simply to gating synchronous with central inspiratory neuron activity. Regularization of heart rate during rapid breathing is associated with loss of the differential inspiratory-expiratory baroreflex responsiveness, which is present at usual breathing rates.