Towards mixed sequence recognition by triple helix formation
Towards mixed sequence recognition by triple helix formation
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DOI：
10.1093/nar/27.7.1569
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发表时间：
1999-04-01
影响因子：
14.9
通讯作者：
Fox, KR
中科院分区：
文献类型：
--
作者：
Gowers, DM;Fox, KR
分子间DNA三螺旋的形成提供了设计具有广泛序列识别特性的化合物的可能性，这些化合物可用作分子生物学中的抗基因剂或工具。这种方法的一个主要限制是这些结构通常限于高嘌呤高嘧啶靶位点。本文综述了已被用来克服这一缺点的策略，并概述了在混合序列DNA目标的三倍体形成的潜力。
The formation of intermolecular DNA triple helices offers the possibility of designing compounds with extensive sequence recognition properties which may be useful as antigene agents or tools in molecular biology. One major limitation of this approach is that these structures are generally restricted to homopurine homopyrimidine target sites. This review describes the strategies that have been employed to overcome this drawback and outlines the potential for tripler formation at mixed sequence DNA targets.