High prevalence of genetically diverse Borrelia bavariensis-like strains in Ixodes persulcatus from Selenge Aimag, Mongolia
High prevalence of genetically diverse Borrelia bavariensis-like strains in Ixodes persulcatus from Selenge Aimag, Mongolia
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DOI：
10.1016/j.ttbdis.2012.08.004
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发表时间：
2013-01-01
影响因子：
3.2
通讯作者：
Fingerle, V.
中科院分区：
文献类型：
--
作者：
Scholz, Holger C.;Margos, G.;Fingerle, V.
在蒙古，莱姆型疏螺旋体病于2003年首次报告。为了确定哪些疏螺旋体可能与蒙古国莱姆型疏螺旋体病的发生有关，对在人类莱姆型疏螺旋体病发病率最高的省份色伦格艾玛格省采集的372只全沟硬蜱进行了实时荧光定量PCR检测。24.5%的硬体检出伯氏疏螺旋体DNA阳性。基于SNP的实时荧光定量聚合酶链式反应和多位点序列分析表明，与巴伐利亚芽孢杆菌(B.garinii OspA)有亲缘关系的菌株(以前称为B.garinii OspA血清型4)是最流行的物种，表现出出人意料的高遗传多样性。(C)2012年爱思唯尔股份有限公司。版权所有。
In Mongolia, Lyme borreliosis was first reported in 2003. To determine which Borrelia species may contribute to the occurrence of Lyme borreliosis in Mongolia, real-time PCR was conducted on 372 adult Ixodes persulcatus ticks collected in Selenge Aimag, the province with the highest incidence of human Lyme borreliosis. 24.5% of ticks were identified to be positive for Borrelia burgdorferi sensu lato DNA. Species differentiation using an SNP-based real-time PCR and multi-locus sequence analysis revealed that strains phylogenetically closely related to B. bavariensis (previously known as B. garinii OspA serotype 4) is the most prevalent species, showing an unexpectedly high genetic diversity. (C) 2012 Elsevier GmbH. All rights reserved.