Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging
Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging
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DOI：
10.1364/ao.45.008142
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发表时间：
2006-11-01
期刊：
影响因子：
1.9
通讯作者：
Boas, David A.
中科院分区：
文献类型：
--
作者：
Joseph, Danny K.;Huppert, Theodore J.;Boas, David A.
尽管大多数当前的漫射光学脑成像系统仅使用最近邻测量几何结构，但是可以通过收集重叠的测量集合来提高成像的空间分辨率和定量准确度。描述了一种连续波漫射光学成像系统，该系统将频率编码与时分复用相结合，以便于重叠测量大脑激活。幻影测量，以确认预期的空间分辨率和定量精度的提高。实验结果表明，该仪器的应用程序成像人脑激活。所观察到的空间分辨率的改善通过功能性磁共振成像证实。(c)2006年美国光学学会。
Although most current diffuse optical brain imaging systems use only nearest-neighbor measurement geometry, the spatial resolution and quantitative accuracy of the imaging can be improved through the collection of overlapping sets of measurements. A continuous-wave diffuse optical imaging system that combines frequency encoding with time-division multiplexing to facilitate overlapping measurements of brain activation is described. Phantom measurements to confirm the expected improvement in spatial resolution and quantitative accuracy are presented. Experimental results showing the application of this instrument for imaging human brain activation are also presented. The observed improvement in spatial resolution is confirmed by functional magnetic resonance imaging. (c) 2006 Optical Society of America.