First artificial receptors and chemosensors toward phosphorylated peptide in aqueous solution
First artificial receptors and chemosensors toward phosphorylated peptide in aqueous solution
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DOI：
10.1021/ja025761b
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发表时间：
2002-06-05
影响因子：
15
通讯作者：
Hamachi, I
中科院分区：
文献类型：
--
作者：
Ojida, A;Mito-oka, Y;Hamachi, I
成功地合成了第一个针对天然磷酸化肽的荧光化学传感器。基于双核锌(II)-二吡啶甲胺的菲(1，2)可以选择性地识别和感觉到磷酸化物种，并随着荧光强度的增加而增加。我们还证明了这些人工受体可以荧光检测水溶液中具有高亲和力的磷酸化肽(>；107m-1)。
The first fluorescent chemosensors toward a native phosphorylated peptide are successfully synthesized. Dinuclear zinc(II)-dipicolylamine-based anthracene (1,2) can selectively recognize and sense phosphorylated species with an increase in the fluorescence intensity. We also demonstrated that these artificial receptors fluorometrically detect a phosphorylated peptide with high affinity (>107M-1) in aqueous solution.