Differences in Ocular Complications Between Candida albicans and Non-albicans Candida Infection Analyzed by Epidemiology and a Mouse Ocular Candidiasis Model.
Differences in Ocular Complications Between Candida albicans and Non-albicans Candida Infection Analyzed by Epidemiology and a Mouse Ocular Candidiasis Model.
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DOI：
10.3389/fmicb.2018.02477
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发表时间：
2018
影响因子：
5.2
通讯作者：
Miyazaki Y
中科院分区：
文献类型：
--
作者：
Abe M;Kinjo Y;Ueno K;Takatsuka S;Nakamura S;Ogura S;Kimura M;Araoka H;Sadamoto S;Shinozaki M;Shibuya K;Yoneyama A;Kaku M;Miyazaki Y
目的：念珠菌属是医院感染的主要原因，包括眼部念珠菌病，但很少有研究检查特定物种侵入眼睛的倾向或诱导的独特免疫反应。本研究通过流行病学和实验，使用小鼠眼部念珠菌病模型，研究了种特异性念珠菌眼部感染的频率和特征。方法：我们回顾了2012年1月至2017年3月期间念珠菌血症患者的病历。我们还评估了眼部真菌负荷，炎症细胞因子和趋化因子的配置文件，并在感染白色念珠菌，光滑念珠菌，或近平滑念珠菌的小鼠炎症细胞配置文件。结果：在研究期间，99例念珠菌血症患者中有20例被眼科医生诊断为眼部念珠菌病。虽然C.近平滑病是最常见的念珠菌血症病原体，只有C.多因素分析显示，白念珠菌感染与眼部念珠菌感染显著相关。在小鼠中，眼部真菌负荷和炎症介质在C.组织病理学分析显示侵袭性念珠菌。被炎性细胞包围的白色念珠菌。眼中性粒细胞和炎性单核细胞数量在C.白色念珠菌感染总结：白色念珠菌与眼部念珠菌病密切相关，因为其具有更强的侵袭能力、诱导炎症介质以及募集中性粒细胞和炎性单核细胞。
Objectives: Candida species are a major cause of hospital infections, including ocular candidiasis, but few studies have examined the propensities of specific species to invade the eye or the unique immunological responses induced. This study examined the frequency and characteristics of species-specific Candida eye infections by epidemiology and experiments using a mouse ocular candidiasis model. Methods: We reviewed medical records of candidemia patients from January 2012 to March 2017. We also evaluated ocular fungal burden, inflammatory cytokine and chemokine profiles, and inflammatory cell profiles in mice infected with Candida albicans, Candida glabrata, or Candida parapsilosis. Results: During the study period, 20 ocular candidiasis cases were diagnosed among 99 candidemia patients examined by ophthalmologists. Although C. parapsilosis was the most frequent candidemia pathogen, only C. albicans infection was significantly associated with ocular candidiasis by multivariate analysis. In mice, ocular fungal burden and inflammatory mediators were significantly higher during C. albicans infection, and histopathological analysis revealed invading C. albicans surrounded by inflammatory cells. Ocular neutrophil and inflammatory monocyte numbers were significantly greater during C. albicans infection. Conclusion: Candida albicans is strongly associated with ocular candidiasis due to greater capacity for invasion, induction of inflammatory mediators, and recruitment of neutrophils and inflammatory monocytes.
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对医疗统计信息的自由使用的易于使用的软件“ EZR”的调查。
影响因子：
4.8
作者：
Kanda Y
通讯作者：
Kanda Y
DOI：
10.1007/s00417-005-0182-5
发表时间：
2006-07-01
影响因子：
2.7
作者：
Takebayashi, Hiroshi;Mizota, Atsushi;Tanaka, Minoru
通讯作者：
Tanaka, Minoru
影响因子：
2.9
作者：
Abe, Masahiro;Kimura, Muneyoshi;Yoneyama, Akiko
通讯作者：
Yoneyama, Akiko
影响因子：
13.7
作者：
DONAHUE, SP;GREVEN, CM;LU, VL
通讯作者：
LU, VL
影响因子：
11.8
作者：
Pappas, Peter G.;Kauffman, Carol A.;Sobel, Jack D.
通讯作者：
Sobel, Jack D.