Dissolving the Missing Heritability Problem
Dissolving the Missing Heritability Problem
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DOI：
10.1086/694007
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发表时间：
2017-12-01
影响因子：
1.7
通讯作者：
Lu, Qiaoying
中科院分区：
文献类型：
--
作者：
Bourrat, Pierrick;Lu, Qiaoying
全基因组关联研究（GWAS）获得的遗传力估计值远低于传统的定量方法。这种现象被称为缺失遗传性问题。通过对GWAS和传统定量方法的分析比较，我们首先发现GWAS的估计包含了除加性遗传方差之外的一些项，而GWAS的估计则不包含加性遗传方差。其次，GWAS在用于估计遗传力时，不考虑跨代传递的附加表观遗传因素，而传统的定量方法则考虑。考虑到这两点，我们表明缺失的遗传性问题在很大程度上是可以解决的。
Heritability estimates obtained from genome-wide association studies (GWAS) are much lower than those of traditional quantitative methods. This phenomenon has been called the missing heritability problem. By analyzing and comparing GWAS and traditional quantitative methods, we first show that the estimates obtained from the latter involve some terms other than additive genetic variance, while the estimates from the former do not. Second, GWAS, when used to estimate heritability, do not take into account additive epigenetic factors transmitted across generations, while traditional quantitative methods do. Given these two points we show that the missing heritability problem can largely be dissolved.