Electron energy‐loss spectroscopy (EELS) of iodine in thyroxine: parameters of radiation‐induced loss of iodine
Electron energy‐loss spectroscopy (EELS) of iodine in thyroxine: parameters of radiation‐induced loss of iodine
复制标题
甲状腺素中碘的电子能量损失谱 (EELS)：辐射引起的碘损失参数
DOI：
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Trendelenburg
中科院分区：
文献类型：
--
作者：
Haking;Richter;Tröster;Spring;Spiess;Trendelenburg
测定了碘在电子辐照过程中的损失，以确定是否可以用电子能谱成像（ESI）检测到碘。由于碘可以与有机分子结合，因此它可以作为生物医学研究中ESI示踪剂的候选物。将甲状腺素溶液涂在碳膜上作为测试样本。甲状腺素含有四个碘原子，共价结合在芳香环上。对于ESI，必须使用比传统电子显微镜更高的剂量。因此，在辐照剂量高达3 × 107 el nm−2后测量碘含量。在不同的样品厚度、温度和剂量率下进行了测量，发现在- 160°C的温度下使用中等剂量率可以用ESI检测到碘。
The loss of iodine during irradiation with electrons was measured in order to determine whether it can be detected by electron spectroscopic imaging (ESI). Since iodine can be bound to organic molecules, it could be a candidate for tracer studies by ESI in biomedical research. A solution of thyroxine spread over a carbon film was used as a test specimen. Thyroxine contains four iodine atoms covalently bound to aromatic rings. For ESI, higher doses have to be used than in conventional electron microscopy. The iodine content was therefore measured after irradiation with doses of up to 3 × 107 el nm−2. The measurements were carried out for different specimen thicknesses, temperatures and dose rates, and it was found that iodine can be detected with ESI if moderate dose rates are used at a temperature of −160 °C.
蛋白质晶体的电子辐射敏感性。
影响因子：
2.2
作者：
Chiu,W;Jeng,TW
通讯作者：
Jeng,TW