Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy.
Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy.
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DOI：
10.1016/j.bbamcr.2015.02.005
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Lavandero S
中科院分区：
文献类型：
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作者：
Westermeier F;Navarro-Marquez M;López-Crisosto C;Bravo-Sagua R;Quiroga C;Bustamante M;Verdejo HE;Zalaquett R;Ibacache M;Parra V;Castro PF;Rothermel BA;Hill JA;Lavandero S
糖尿病性心肌病(DCM)是长期存在的2型糖尿病(T2 DM)的常见后果，包括心脏的结构、形态、功能和代谢异常。心肌的能量代谢依赖于线粒体，线粒体必须产生足够的ATP来满足心肌的高能量需求。功能障碍的线粒体参与了糖尿病心脏病的病理生理过程。大量证据表明心肌胰岛素抵抗与DCM的发病机制有关。最近的研究表明，胰岛素信号通过影响生理条件下心肌细胞线粒体的动力学和功能来影响心肌能量代谢。然而，对糖尿病心肌病中胰岛素信号和线粒体网络结构变化的分子机制缺乏全面的了解。这篇综述总结了我们目前对胰岛素信号缺陷如何影响糖尿病心肌病心脏功能的认识，并讨论了线粒体动力学的潜在作用。
Diabetic cardiomyopathy (DCM) is a common consequence of longstanding type 2 diabetes mellitus (T2DM) and encompasses structural, morphological, functional, and metabolic abnormalities in the heart. Myocardial energy metabolism depends on mitochondria, which must generate sufficient ATP to meet the high energy demands of the myocardium. Dysfunctional mitochondria are involved in the pathophysiology of diabetic heart disease. A large body of evidence implicates myocardial insulin resistance in the pathogenesis of DCM. Recent studies show that insulin signaling influences myocardial energy metabolism by impacting cardiomyocyte mitochondrial dynamics and function under physiological conditions. However, comprehensive understanding of molecular mechanisms linking insulin signaling and changes in the architecture of the mitochondrial network in diabetic cardiomyopathy is lacking. This review summarizes our current understanding of how defective insulin signaling impacts cardiac function in diabetic cardiomyopathy and discusses the potential role of mitochondrial dynamics.