Circadian rest-activity rhythm and longitudinal brain changes underlying late-life cognitive decline.
Circadian rest-activity rhythm and longitudinal brain changes underlying late-life cognitive decline.
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DOI：
10.1111/pcn.13521
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发表时间：
2023-04
影响因子：
11.9
通讯作者：
KBASE Research Group
中科院分区：
文献类型：
--
作者：
Jeon, So Yeon;Byun, Min Soo;Yi, Dahyun;Jung, Gijung;Lee, Jun-Young;Kim, Yu Kyeong;Sohn, Chul-Ho;Kang, Koung Mi;Lee, Yu Jin;Lee, Dong Young;KBASE Research Group
昼夜休息-活动节律（RAR）改变与老年认知能力加速下降之间关系的神经生物学基础尚不清楚。在本研究中，客观测量的昼夜节律RAR与体内阿尔茨海默病（AD）病理和脑血管损伤的纵向关系在无痴呆的老年人中进行了研究。本研究包括129名无痴呆的参与者，他们参加了KBASE（韩国脑衰老研究，用于阿尔茨海默病的早期诊断和预测）队列。所有参与者在基线和2年随访评估时均接受了活动摄影和连续两次[11C]匹兹堡化合物- b正电子发射断层扫描（PET）、[18F]氟脱氧葡萄糖-PET、磁共振成像和基本精神状态检查（MMSE）。研究了昼夜节律RAR与神经影像学指标的年化变化之间的关系，包括全球淀粉样蛋白保留、ad特征区脑糖代谢（AD-CM）和白质高强度体积。基线顶相延迟与2年内AD-CM的年化下降显著相关，但与其他神经影像学指标无关。相比之下，基线时的其他昼夜节律RAR参数与任何神经影像学测量的年化变化无关。AD-CM的年化下降也与MMSE评分的年化变化显著正相关。此外，一项中介分析显示，AD-CM的更大降低介导了基线时延迟顶相对MMSE评分更快下降的影响。研究结果表明，晚年的顶相延迟可能导致或预测ad特征大脑区域的代谢降低，这是近期认知能力下降的基础。
The neurobiological substrates underlying the relationship of circadian rest-activity rhythm (RAR) alteration with accelerated late-life cognitive decline are not clearly understood. In the present study, the longitudinal relationship of objectively measured circadian RAR with in vivo Alzheimer disease (AD) pathologies and cerebrovascular injury was investigated in older adults without dementia. The present study included 129 participants without dementia who participated in the KBASE (Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer’s Disease) cohort. All participants underwent actigraphy at baseline and two consecutive [11C] Pittsburgh compound-B positron emission tomography (PET), [18F] fluorodeoxyglucose-PET, magnetic resonance imaging, and Mini-Mental State Examination (MMSE) at baseline and at a 2-year follow-up assessment. The associations of circadian RAR with annualized change in neuroimaging measures including global amyloid-beta retention, AD-signature region cerebral glucose metabolism (AD-CM), and white matter hyperintensity volume were examined. Delayed acrophase at baseline was significantly associated with greater annualized decline of AD-CM over a 2-year period, but not with that of other neuroimaging measures. In contrast, other circadian RAR parameters at baseline had no association with annualized change of any neuroimaging measures. Annualized decline of AD-CM was also significantly positively associated with the annual change in MMSE scores. Furthermore, a mediation analysis showed that greater reduction in AD-CM mediated the effect of delayed acrophase at baseline on faster decline of MMSE score. The findings indicate that delayed acrophase in late life may cause or predict hypometabolism at AD-signature brain regions, which underlies cognitive decline in the near future.
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一项基于人群的前瞻性研究对香港健康居住的老年人的静息节奏和轻度认知障碍。
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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影响因子：
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影响因子：
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