Effects of dietary salt levels on monocytic cells and immune responses in healthy human subjects: a longitudinal study.
Effects of dietary salt levels on monocytic cells and immune responses in healthy human subjects: a longitudinal study.
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DOI：
10.1016/j.trsl.2014.11.007
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Choukèr A
中科院分区：
文献类型：
--
作者：
Yi B;Titze J;Rykova M;Feuerecker M;Vassilieva G;Nichiporuk I;Schelling G;Morukov B;Choukèr A
越来越多的证据表明，过量食用盐会对人类健康造成风险，公共卫生当局建议将每日盐摄入量从目前的平均约12 g/d减少到5-6 g/d。对小鼠的研究表明，氯化钠在免疫系统的调节中起作用，高盐饮食会促进组织炎症和自身免疫性疾病。然而，饮食盐对人体免疫力的转化证据很少。我们使用了一种实验方法，将健康受试者的盐摄入量固定在12，9和6 g/d，持续数月，并检查了盐摄入量与免疫系统变化之间的关系。从每个盐摄入期的终点采集血液样本。通过外周血白细胞表型分析监测免疫表型变化。我们通过细胞因子对有丝分裂原刺激的反应来评估免疫功能的变化。结果显示，与低盐饮食的相同受试者相比，高盐饮食12 g/d的受试者显示出显著更高的免疫细胞单核细胞数量，相关性检验显示盐摄入水平与单核细胞数量之间存在强正相关。盐摄入量的减少伴随着促炎细胞因子白细胞介素（IL）-6和IL-23的产生减少，沿着抗炎细胞因子IL-10的产生能力增强。这些结果表明，在健康人群中，高盐饮食有可能导致过度的免疫反应，这可能会破坏免疫稳态，减少习惯性饮食盐摄入量可能会诱导潜在的有益免疫改变。
Increasing evidence indicated that excess salt consumption can impose risks on human health and a reduction in daily salt intake from the current average of approximately 12 g/d to 5–6 g/d was suggested by public health authorities. The studies on mice have revealed that sodium chloride plays a role in the modulation of the immune system and a high-salt diet can promote tissue inflammation and autoimmune disease. However, translational evidence of dietary salt on human immunity is scarce. We used an experimental approach of fixing salt intake of healthy human subjects at 12, 9, and 6 g/d for months and examined the relationship between salt-intake levels and changes in the immune system. Blood samples were taken from the end point of each salt intake period. Immune phenotype changes were monitored through peripheral leukocyte phenotype analysis. We assessed immune function changes through the characterization of cytokine profiles in response to mitogen stimulation. The results showed that subjects on the high-salt diet of 12 g/d displayed a significantly higher number of immune cell monocytes compared with the same subjects on a lower-salt diet, and correlation test revealed a strong positive association between salt-intake levels and monocyte numbers. The decrease in salt intake was accompanied by reduced production of proinflammatory cytokines interleukin (IL)-6 and IL-23, along with enhanced producing ability of anti-inflammatory cytokine IL-10. These results suggest that in healthy humans high-salt diet has a potential to bring about excessive immune response, which can be damaging to immune homeostasis, and a reduction in habitual dietary salt intake may induce potentially beneficial immune alterations.
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影响因子：
20.1
作者：
Ismahil MA;Hamid T;Bansal SS;Patel B;Kingery JR;Prabhu SD
通讯作者：
Prabhu SD
影响因子：
3.7
作者：
Müller S;Quast T;Schröder A;Hucke S;Klotz L;Jantsch J;Gerzer R;Hemmersbach R;Kolanus W
通讯作者：
Kolanus W
影响因子：
5.4
作者：
Gu, Yongpeng;Yang, Jianfei;Ouyang, Xinshou;Liu, Weicheng;Li, Hongxing;Yang, Jianjun;Bromberg, Jonathan;Chen, Shu-Hsia;Mayer, Lloyd;Unkeless, Jay C.;Xiong, Huabao
通讯作者：
Xiong, Huabao
影响因子：
20.3
作者：
Hirakawa, Satoshi;Brown, Lawrence F.;Detmar, Michael
通讯作者：
Detmar, Michael
影响因子：
64.8
作者：
Kleinewietfeld, Markus;Manzel, Arndt;Titze, Jens;Kvakan, Heda;Yosef, Nir;Linker, Ralf A.;Muller, Dominik N.;Hafler, David A.
通讯作者：
Hafler, David A.