Effects of ovariectomy and estrogen treatment on learning and hippocampal neurotransmitters in mice
Effects of ovariectomy and estrogen treatment on learning and hippocampal neurotransmitters in mice
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DOI：
10.1006/hbeh.2001.1738
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发表时间：
2002-02-01
影响因子：
3.5
通讯作者：
Tanila, H
中科院分区：
文献类型：
--
作者：
Heikkinen, T;Puoliväli, J;Tanila, H
本研究通过t型迷宫的位置识别任务和桡骨臂迷宫（RAM）的1/8臂诱饵任务，研究了长期雌激素治疗（sc - 17β -雌二醇微丸）对C57BL/6J雌雄小鼠学习的影响。此外，在研究结束时测量海马单胺和ChAT活性，并与任务表现相关。雌性假手术（性腺完整）和去卵巢（OVX）小鼠在行为测试前用雌激素治疗7天或40天，雄性完整小鼠在行为测试前用雌激素治疗7天。在假手术小鼠中，40天的雌激素治疗改善了RAM的表现，而在OVX小鼠中，7天和40天的雌激素治疗均改善了迷宫任务的表现。雌激素治疗也改善了雄性RAM的表现。OVX小鼠海马ChAT、NA、5-HIAA和DOPAC水平降低。此外，雌激素治疗对假手术小鼠海马5-羟色胺及其代谢物5-HIAA水平的影响与OVX小鼠不同。我们没有发现认知测量和神经化学变量之间的相关性。本研究为雌激素对小鼠学习和海马神经递质的影响提供了新的信息。(C) 2002 Elsevier Science （USA）。
This study examined the effects of long-term estrogen treatment (sc 17beta-estradiol minipellets) on learning in C57BL/6J female and male mice using a position discrimination task in the T-maze and a win-stay task (1/8 arms baited) in the radial arm maze (RAM). In addition, hippocampal monoamines and ChAT activity were measured at the end of the study and correlated to task performance. Female sham-operated (gonadally intact) and ovariectomized (OVX) mice were treated with estrogen either for 7 or 40 days before the behavioral tests and intact male mice for 7 days before the behavioral tests. In sham-operated mice the 40-day estrogen treatment improved RAM performance and in OVX mice both the 7- and 40-day estrogen treatments improved the performance in both maze tasks. The estrogen treatment also improved RAM performance in males. The hippocampal ChAT, NA, 5-HIAA, and DOPAC levels were decreased in OVX mice. Furthermore, the effects of estrogen treatment on the levels of hippocampal 5-HT and its metabolite 5-HIAA were different in sham-operated than in OVX mice. We could find no correlation between cognitive measures and neurochemical variables. This study gives new information about the effects of estrogen on learning and hippocampal neurotransmitters in mice. (C) 2002 Elsevier Science (USA).