Aspirin for dual prevention of venous and arterial thrombosis.
Aspirin for dual prevention of venous and arterial thrombosis.
复制标题
阿司匹林用于双重预防静脉和动脉血栓形成。
DOI：
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发表时间：
2012
影响因子：
158.5
通讯作者：
T. Warkentin
中科院分区：
文献类型：
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作者：
T. Warkentin
阿司匹林通常被认为是一种预防动脉血栓形成的药物，这种作用是通过抑制血小板环氧合酶-1，导致血栓素A2(血小板激活二十烷类化合物)合成减少而实现的。在高危患者中，阿司匹林可将动脉血栓的发生率降低四分之一。1 1977年，阿司匹林(每天两次，剂量为600毫克)在接受髋关节成形术后给患者服用时，被证明可以降低静脉血栓形成的风险。2 35年后，指南将阿司匹林作为预防骨科手术后静脉血栓形成的一种选择。3然而，许多专家认为阿司匹林在这方面是次要的治疗方法。
Aspirin is conventionally regarded as an agent that prevents arterial thrombosis, an effect mediated through inhibition of platelet cyclooxygenase-1, resulting in decreased synthesis of thromboxane A2 (platelet-activating eicosanoid). In high-risk patients, aspirin reduces by one quarter the frequency of arterial thrombosis.1 In 1977, aspirin (at a dose of 600 mg twice daily) was shown to reduce the risk of venous thrombosis when it was given to patients after they had undergone hip arthoplasty.2 Thirty-five years later, guidelines include aspirin as one option for preventing venous thromboembolism after orthopedic surgery.3 However, many experts regard aspirin as inferior therapy for this . . .