Systematic Understanding of Pathophysiological Mechanisms of Oxidative Stress-Related Conditions-Diabetes Mellitus, Cardiovascular Diseases, and Ischemia-Reperfusion Injury.
Systematic Understanding of Pathophysiological Mechanisms of Oxidative Stress-Related Conditions-Diabetes Mellitus, Cardiovascular Diseases, and Ischemia-Reperfusion Injury.
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DOI：
10.3389/fcvm.2021.649785
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发表时间：
2021
影响因子：
3.6
通讯作者：
Takahashi K
中科院分区：
文献类型：
--
作者：
Wang M;Liu Y;Liang Y;Naruse K;Takahashi K
活性氧(ROS)在生理条件下参与细胞内信号转导，在高血压、缺血性心脏病、糖尿病等疾病以及衰老过程中发挥重要作用。ROS的影响对糖尿病患者心血管疾病(CVD)的多发有一定影响。在这篇综述中，我们从ROS的角度探讨糖尿病与心血管疾病之间的病理生理关系。此外，考虑到缺血再灌流过程中ROS升高引起的器官损伤，我们还讨论了心和肺损伤。此外，我们还以瞬时受体电位通道和L类钙通道作为ROS在ROS诱导的组织损伤中的分子靶点，并对损伤的病理生理机制进行了讨论。
Reactive oxygen species (ROS) plays a role in intracellular signal transduction under physiological conditions while also playing an essential role in diseases such as hypertension, ischemic heart disease, and diabetes, as well as in the process of aging. The influence of ROS has some influence on the frequent occurrence of cardiovascular diseases (CVD) in diabetic patients. In this review, we considered the pathophysiological relationship between diabetes and CVD from the perspective of ROS. In addition, considering organ damage due to ROS elevation during ischemia–reperfusion, we discussed heart and lung injuries. Furthermore, we have focused on the transient receptor potential (TRP) channels and L-type calcium channels as molecular targets for ROS in ROS-induced tissue damages and have discussed about the pathophysiological mechanism of the injury.