Antimicrobial Activity of Resveratrol Analogues
Antimicrobial Activity of Resveratrol Analogues
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DOI：
10.3390/molecules19067679
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发表时间：
2014-06-01
期刊：
影响因子：
4.6
通讯作者：
Adrian, Marielle
中科院分区：
文献类型：
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作者：
Chalal, Malik;Klinguer, Agnes;Adrian, Marielle
二苯乙烯，特别是白藜芦醇及其衍生物，因其对广泛的医学疾病的积极作用而闻名，大量已发表的研究表明。一个较少研究的领域是它们的抗菌特性。通过Wittig或Heck反应合成了13种反式白藜芦醇类似物，并对葡萄病害病原菌进行了抑菌活性评价。整个系列，连同白藜芦醇，首先评估了葡萄浆原菌（负责霜霉病的卵菌）的游动孢子流动性和产孢水平。二苯乙烯显示出从低到高的活性谱。其中6个，包括最活跃的，随后在灰霉菌（灰霉病的真菌）的发展上进行了测试。研究结果使我们能够鉴定出对葡萄病原菌最具活性的二苯乙烯类化合物，比较所评价的二苯乙烯类化合物的抑菌活性，并讨论其化学结构（甲氧基和羟基的数量和位置）与抑菌活性之间的关系。
Stilbenes, especially resveratrol and its derivatives, have become famous for their positive effects on a wide range of medical disorders, as indicated by a huge number of published studies. A less investigated area of research is their antimicrobial properties. A series of 13 trans-resveratrol analogues was synthesized via Wittig or Heck reactions, and their antimicrobial activity assessed on two different grapevine pathogens responsible for severe diseases in the vineyard. The entire series, together with resveratrol, was first evaluated on the zoospore mobility and sporulation level of Plasmopara viticola (the oomycete responsible for downy mildew). Stilbenes displayed a spectrum of activity ranging from low to high. Six of them, including the most active ones, were subsequently tested on the development of Botrytis cinerea (fungus responsible for grey mold). The results obtained allowed us to identify the most active stilbenes against both grapevine pathogens, to compare the antimicrobial activity of the evaluated series of stilbenes, and to discuss the relationship between their chemical structure ( number and position of methoxy and hydroxy groups) and antimicrobial activity.