Characterization of the surface properties of MgO using paper spray mass spectrometry
Characterization of the surface properties of MgO using paper spray mass spectrometry
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使用纸喷雾质谱法表征 MgO 的表面性质
DOI：
10.1002/rcm.7635
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发表时间：
2016
影响因子：
2
通讯作者：
Zhang Zhiping
中科院分区：
文献类型：
--
作者：
Zheng Yajun;Zhang Xiaoling;Bai Zongquan;Zhang Zhiping
在制备不同形态氧化镁（MgO）方面已经取得了重大进展，但对MgO形态与其与治疗药物相互作用之间的关系研究甚少。在此，我们使用纸喷雾质谱法研究了不同形态的氧化镁与治疗药物之间的相互作用。方法采用易沉淀法制备不同形态的MgO，包括梯形、针状、花状和巢状结构。然后通过真空过滤策略将获得的MgO颗粒涂覆在滤纸表面。以不同MgO形态的涂布纸为底物，采用纸喷雾质谱法研究不同MgO与治疗药物的相互作用。结果通过研究不同形态MgO涂布纸与治疗药物的相互作用，发现与梯形、针状和巢状MgO涂布纸相比，花状MgO涂布纸由于其表面碱性较弱，更容易洗脱干血斑（DBS）中的不同药物。此外，不同药物在喷纸过程中的信号强度高度依赖于它们的洗脱行为。结论纸喷雾质谱法（MS）为研究不同结构氧化镁的表面性质提供了一条途径。MgO的表面碱度对DBS中治疗药物的洗脱行为起着至关重要的作用，更有利的洗脱行为往往导致更高的MS信号。版权所有©2016 John Wiley & Sons， Ltd。
RationaleSignificant advances have been made in the preparation of different morphologies of magnesium oxide (MgO), but the relationship between MgO morphology and its interactions with therapeutic drugs is rarely studied. Herein, we investigated the interactions between different morphologies of MgO and therapeutic drugs using paper spray mass spectrometry.MethodsDifferent morphologies of MgO including trapezoidal, needle‐like, flower‐like and nest‐like structures were prepared through a facile precipitation method. The as‐obtained MgO particles were then coated onto the surface of filter paper via vacuum filtration strategy. The coated papers with different morphologies of MgO were used as the substrates for paper spray mass spectrometry to explore the interactions between different MgO and therapeutic drugs.ResultsThrough investigating the interactions between different morphologies of MgO coated papers and therapeutic drugs, it demonstrated that, in contrast to the trapezoidal, needle‐like and nest‐like MgO coated papers, different drugs in dried blood spots (DBS) were more favourably eluted off from the paper coated with flower‐like MgO due to its weaker surface basicity. Also, the signal intensities of different drugs during paper spray were highly dependent on their elution behaviours.ConclusionsPaper spray mass spectrometry (MS) provides an avenue to elaborate the surface properties of MgO with different structures. The surface basicity of MgO played a crucial role in determining the elution behaviours of therapeutic drugs in DBS, and a more favourable elution behaviour tended to result in a higher MS signal. Copyright © 2016 John Wiley & Sons, Ltd.