One-Step Preparation of Thermo-Responsive Poly(N-isopropylacrylamide)-Based Block Copolymer Nanoparticles by Aqueous Photoinitiated Polymerization-Induced Self-Assembly
One-Step Preparation of Thermo-Responsive Poly(N-isopropylacrylamide)-Based Block Copolymer Nanoparticles by Aqueous Photoinitiated Polymerization-Induced Self-Assembly
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DOI：
10.1002/marc.202100201
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发表时间：
2021-06-17
影响因子：
4.6
通讯作者：
Tan, Jianbo
中科院分区：
文献类型：
--
作者：
He, Jun;Lin, Dongni;Tan, Jianbo
聚N-异丙基丙烯酰胺（PNIPAM）是一种重要的温敏聚合物，在许多领域有着广泛的应用。然而，在高固体下制备具有更高阶形态的PNIPAM基嵌段共聚物纳米颗粒是具有挑战性的。在此，水性光引发聚合诱导的自组装（光-PISA）的N-异丙基丙烯酰胺（NIPAM）使用不对称交联剂的开发用于一步制备PNIPAM为基础的嵌段共聚物纳米粒子具有各种形态（球，蠕虫，和囊泡）。结果表明，反应温度对嵌段共聚物纳米颗粒的聚合动力学和形态有很大影响。嵌入PNIPAM核内的可逆加成-断裂链转移（RAFT）反应基团为进一步官能化提供了前景。在室温下，采用种子光致PISA法制备了具有不同表面性质的PNIPAM基嵌段共聚物纳米粒子。最后，这些嵌段共聚物纳米颗粒还用作添加剂，以通过共价交联来调节水凝胶的机械性能。
Poly(N-isopropylacrylamide) (PNIPAM) is an important thermo-responsive polymer that finds applications in many areas. However, the preparation of PNIPAM-based block copolymer nanoparticles with higher-order morphologies at high solids is challenging. Herein, aqueous photoinitiated polymerization-induced self-assembly (photo-PISA) of N-isopropylacrylamide (NIPAM) using an asymmetrical cross-linker is developed for one-step preparation of PNIPAM-based block copolymer nanoparticles with various morphologies (spheres, worms, and vesicles). It is demonstrated that reaction temperature has a great effect on both polymerization kinetics and morphologies of block copolymer nanoparticles. Reversible addition-fragmentation chain transfer (RAFT) reactive groups embedded inside the PNIPAM core provide a landscape for further functionalization. PNIPAM-based block copolymer nanoparticles with different surface properties are prepared by seeded photo-PISA at room temperature. Finally, these block copolymer nanoparticles are also used as additives to tune mechanical properties of hydrogels via covalent cross-linking.