Gender-related functional connectivity and craving during gaming and immediate abstinence during a mandatory break: Implications for development and progression of internet gaming disorder
Gender-related functional connectivity and craving during gaming and immediate abstinence during a mandatory break: Implications for development and progression of internet gaming disorder
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DOI：
10.1016/j.pnpbp.2018.04.009
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发表时间：
2019-01-10
影响因子：
5.6
通讯作者：
Potenza, Marc N.
中科院分区：
文献类型：
--
作者：
Dong, Guangheng;Wang, Ziliang;Potenza, Marc N.
背景资料：虽然男性更频繁地发展网络游戏障碍（IGD）相比，女性，很少有研究探讨性别相关的神经认知差异IGD.Task和设计：功能磁共振成像和主观数据收集119名受试者（IGD，男29，女25;娱乐游戏使用（RGU），男34，女31），当他们积极玩游戏，并在强制性的强制性休息。分析调查组（IGD，RGU）和性别（男性，女性）的功能连接（FC）的执行控制和奖励系统与背外侧前额叶皮层（DLPFC）和纹状体，分别进行。FC和主观渴望measures.Results之间的相关性也被计算：游戏组通过性别的相互作用。在游戏过程中，男性的DLPFC和上级额回之间的FC相对减少，纹状体和丘脑之间的FC相对增加，而女性则没有。在强制性休息期间，DLPFC和上级额回之间的FC以及纹状体和丘脑之间的FC的变化因性别而异，在女性中观察到更大的RGU-IGD差异。FC和自我报告的渴望之间的显着相关性observed.Conclusions：在游戏和强制性的休息，涉及执行控制和奖励处理的大脑区域表现出不同性别的FC的变化。涉及执行控制的大脑区域显示差异FC在男性在游戏过程中，FC在强制性的强制性休息出现相关的两种性别，也许特别是女性。研究结果表明，为什么男性似乎更容易发展IGD，以及为什么IGD患者停止游戏特别困难，可能是可能的神经机制。
Background: Although males more frequently develop Internet gaming disorder (IGD) as compared with females, few studies have examined gender-related neurocognitive differences in IGD.Task and design: fMRI and subjective data were collected from 119 subjects (IGD, male 29, female 25; recreational game use (RGU), male 34, female 31) when they were actively playing games and during a forced mandatory break. Analyses investigating effects of group (IGD, RGU) and gender (male, female) on the functional connectivity (FC) of executive control and reward systems linked to the dorsolateral prefrontal cortex (DLPFC) and striatum, respectively, were performed. Correlations between FC and subjective craving measures were also calculated.Results: Gaming-group-by-gender interactions were observed. During gaming in males but not in females, the FC between the DLPFC and superior frontal gyrus was relatively decreased, and that between the striatum and thalamus was relatively increased. During the mandatory break, changes in the FC between DLPFC and superior frontal gyrus and the FC between the striatum and thalamus varied by gender with greater RGU-IGD differences observed in females. Significant correlations between FC and self-reported craving were observed.Conclusions: During both gaming and a forced mandatory break, brain regions implicated in executive control and reward processing showed changes in FC that varied by gender. Brain regions implicated in executive control showed differential FC in males during gaming, and FC during the forced mandatory break appeared relevant to both genders, and perhaps particularly for females. The findings suggest possible neural mechanisms for why males appear more likely to develop IGD, and why it may be particularly difficult for individuals with IGD to cease gaming.