Mother to young transmission of Brucella abortus infection in mouse model.
Mother to young transmission of Brucella abortus infection in mouse model.
复制标题
小鼠模型中流产布鲁氏菌感染的母婴传播。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
N. Bosseray
中科院分区：
文献类型：
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作者：
N. Bosseray
用2 × 10（5）B腹腔内激发妊娠小鼠。流产菌株544（Weybridge）或其两种突变菌株之一。通过尸检时计数脾脏、肝脏和肺部中的布鲁氏菌，评估布鲁氏菌病向幼鼠的传播。新生儿，在任何哺乳之前被取下，要么被尸检，要么被交给寄养护士，要么被感染，要么正常。在第10、20和30天对幼鼠进行尸检。60%的新生儿在出生时就受到感染。感染强度低，主要局限于肝脏。无论护士的感染状况如何，感染都以相同的频率持续存在，并且没有任何疾病迹象。在114只对照小鼠中，仅在1只小鼠上观察到由感染或正常母鼠产下的幼鼠通过感染护士的母乳接触感染。然而，感染的强度和位置取决于年龄和护士的感染状况。肝脏感染强度随年龄增长而降低。脾脏感染的频率和强度均随年龄增长而增加。强度增加更迅速的婴儿小鼠饲养的正常非感染护士。肺感染的频率和强度增加时，由感染的护士饲养的幼鼠，而在20和30天之间，这种肺部感染减少和消失时，由正常的护士饲养的幼鼠。
Pregnant mice were challenged intraperitoneally with 2 X 10(5) B. abortus strain 544 (Weybridge), or with one of its two mutant strains, at day 7 of pregnancy. Transmission of brucellosis to infant mice was assessed by enumeration of brucella in spleen, liver and lungs at autopsy. Newborns, taken before any suckling were either autopsied or given to foster nurses, either infected or normal. Infant mice were autopsied at days 10, 20 and 30. Sixty per cent of the newborns were infected at birth. Infection was of low intensity and mainly localized in liver. Infection persisted at the same frequency whatever infection status of the nurses and without any sign of illness. Contact infection of infant mice born from infected or normal dams by suckling milk from infected nurses was observed only on one infant mouse out of 114 controlled. However, intensity and location of infection depended on age and on infection status of the nurses. Intensity of liver infection decreased with age. Splenic infection increased both in frequency and intensity with age. Intensity increased more rapidly on infant mice bred by normal non-infected nurses. Lung infection increased both in frequency and intensity when infant mice were bred by infected nurses whereas, between 20 and 30 days, this lung infection decreased and disappeared when infant mice were bred by normal nurses.