18F-FDG PET in the detection of extrahepatic metastases from hepatocellular carcinoma
18F-FDG PET in the detection of extrahepatic metastases from hepatocellular carcinoma
复制标题
DOI：
10.1007/s00535-004-1427-5
复制
发表时间：
2004-10-01
影响因子：
6.3
通讯作者：
Nakamura, S
中科院分区：
文献类型：
--
作者：
Sugiyama, M;Sakahara, H;Nakamura, S
背景。使用 F-18-氟-2-脱氧-D-葡萄糖 (F-18-FDG) 的正电子发射断层扫描 (PET) 可用于检测多种恶性肿瘤的远处转移。然而，其检测肝细胞癌（HCC）远处转移的效率尚未得到研究。本研究的目的是评估 F-18-FDG PET 在检测 HCC 肝外转移方面的有用性。方法。 19 名疑似肝外 HCC 患者接受了 F-18-FDG PET 检查。 14名患者（A组）有肝外病变，这是通过常规研究发现的。 5 名患者（B 组）的常规影像学检查未发现肝外或肝内病变，但肿瘤标志物水平升高。将 PET 结果与组织病理学或临床随访获得的结果进行比较。结果。 F-18-FDG PET对于最大直径大于1cm的肝外转移灶的检出率为83%（29个转移灶中的24个），对于小于或等于1cm的肝外转移灶的检出率为13%（8个转移灶中的1个）。 PET 显示骨扫描未显示的两个骨转移，并检测到计算机断层扫描未得出结论的淋巴结转移和肠转移。 A组5例患者根据PET检查结果切除肝外病灶。在B组的所有患者中，PET结果显示肝外转移真阴性，但有4名患者在4个月内在肝脏中检测到HCC。两组均未出现假阳性病变。结论。这项初步研究表明，F-18-FDG PET 可以提供额外的信息，有助于治疗疑似肝外转移的 HCC 患者。
Background. Positron emission tomography (PET) with F-18-fluoro-2-deoxy-D-glucose (F-18-FDG) is useful in detecting distant metastases from a variety of malignancies. However, its efficiency in detecting distant metastases from hepatocellular carcinoma (HCC) has not been investigated. The aim of this study was to evaluate the usefulness of F-18-FDG PET for the detection of extrahepatic metastases from HCC. Methods. Nineteen patients suspected of having extrahepatic HCC underwent F-18-FDG PET. Fourteen patients (group A) had extrahepatic lesions, which were detected by conventional studies. In five patients (group B), conventional imaging showed no extra- or intrahepatic lesions, but the tumor marker levels were elevated. The PET results were compared with those obtained by histopathology or by clinical follow-up. Results. The detection rate of F-18-FDG PET was 83% (24 of 29 metastases) for extrahepatic metastases larger than 1 cm in greatest diameter and 13% (1 of 8 metastases) for lesions less than or equal to 1 cm. PET revealed two bone metastases not depicted by bone scan, and detected the nodal metastasis and intestinal metastases inconclusive on computed tomography. Extrahepatic lesions were resected in 5 patients of group A on the basis of PET findings. In all patients of group B, PET results were true negative for extrahepatic metastases, but HCCs were detected in the liver within 4 months in 4 patients. These were no false-positive lesions in either group. Conclusions. This preliminary study suggested that F-18-FDG PET could provide additional information and contribute to the management of HCC patients suspected of having extrahepatic metastases.