Zerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm.
Zerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm.
复制标题
零紫bismuth纳米颗粒抑制链球菌的生长和生物膜的形成。
DOI：
10.2147/ijn.s29854
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发表时间：
2012
影响因子：
8
通讯作者：
Cabral-Romero C
中科院分区：
文献类型：
--
作者：
Hernandez-Delgadillo R;Velasco-Arias D;Diaz D;Arevalo-Niño K;Garza-Enriquez M;De la Garza-Ramos MA;Cabral-Romero C
尽管不断努力，但病原菌对常见抗生素的耐药性日益普遍，已成为现代医学最关注的问题之一。纳米材料在许多领域都有应用，包括生物科学和医学。虽然一些铋的衍生物已被用于治疗呕吐、恶心、腹泻和胃痛，但零价铋纳米颗粒的杀菌活性尚未被研究。本研究的目的是分析纳米铋对口腔细菌的抗菌活性及其抗生物被膜的能力。结果表明，稳定的胶体铋纳米粒子对变形链球菌的生长具有69%的抑菌活性，并完全抑制了生物被膜的形成。这些结果与最常用的口腔防腐剂洗必泰相似。纳米铋对变形链球菌生长的最小抑制浓度为0.5 mM。这些结果表明，零价铋纳米颗粒可能是一种有趣的抗菌剂，可用于口腔防腐制剂。
Despite continuous efforts, the increasing prevalence of resistance among pathogenic bacteria to common antibiotics has become one of the most significant concerns in modern medicine. Nanostructured materials are used in many fields, including biological sciences and medicine. While some bismuth derivatives has been used in medicine to treat vomiting, nausea, diarrhea, and stomach pain, the biocidal activity of zerovalent bismuth nanoparticles has not yet been studied. The objective of this investigation was to analyze the antimicrobial activity of bismuth nanoparticles against oral bacteria and their antibiofilm capabilities. Our results showed that stable colloidal bismuth nanoparticles had 69% antimicrobial activity against Streptococcus mutans growth and achieved complete inhibition of biofilm formation. These results are similar to those obtained with chlorhexidine, the most commonly used oral antiseptic agent. The minimal inhibitory concentration of bismuth nanoparticles that interfered with S. mutans growth was 0.5 mM. These results suggest that zerovalent bismuth nanoparticles could be an interesting antimicrobial agent to be incorporated into an oral antiseptic preparation.