Cortisol Profile Mediates the Relation Between Childhood Neglect and Pain and Emotional Symptoms among Patients with Fibromyalgia.
Cortisol Profile Mediates the Relation Between Childhood Neglect and Pain and Emotional Symptoms among Patients with Fibromyalgia.
复制标题
皮质醇谱介导纤维肌痛患者童年忽视与疼痛和情绪症状之间的关系。
DOI：
10.1007/s12160-015-9734-z
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Ciaramitaro,MarissaC
中科院分区：
文献类型：
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作者：
Yeung,EllenW;Davis,MaryC;Ciaramitaro,MarissaC
背景儿童创伤与成人慢性疼痛和情绪症状之间的关系已经得到了很好的记录，尽管调节这种联系的生理机制还没有详细阐述。目的本研究探讨皮质醇在纤维肌痛(FM)患者的童年虐待与疼痛和情感症状之间的联系中的中介作用。方法79名纤维肌痛患者首先提供了童年虐待的回顾性自我报告，然后参加了一次标准化的会议，在此期间皮质醇被采样1.5小时，随后完成了日常疼痛、抑郁症状和焦虑的评估。潜在生长曲线模型对假设的中介模型进行了估计。结果儿童时期的忽视预示着皮质醇水平的平坦，而皮质醇水平反过来又预示着日常疼痛和情绪症状的增加。皮质醇水平部分调节忽视-症状关系。结论早期虐待可能对内分泌调节产生持久影响，从而导致成人慢性疼痛的疼痛和情绪症状。
BackgroundThe relation between childhood trauma and chronic pain and emotional symptoms in adulthood has been well-documented, although physiological mechanisms mediating this link have not been elaborated.PurposeThis study examined the mediating role of cortisol profile in the linkage between childhood maltreatment and pain and emotional symptoms in individuals with fibromyalgia (FM).MethodsOne hundred seventy-nine adults with FM first provided retrospective self-reports of childhood maltreatment, then attended a standardized session during which cortisol was sampled across 1.5 hours and, subsequently, completed assessments of daily pain, depressive symptoms, and anxiety. Latent growth curve modeling estimated the hypothesized mediation models.ResultsChildhood neglect predicted a flattened cortisol profile, which, in turn, predicted elevated daily pain and emotional symptoms. The cortisol profile partially mediated the neglect-symptom relation.ConclusionsEarly maltreatment may exert enduring effects on endocrine regulation that contributes to pain and emotional symptoms in adults with chronic pain.