The Global Burden of Cardiovascular Disease: The Role of Endothelial Function and Arterial Elasticity in Cardiovascular Disease as Novel and Emerging Biomarkers.
The Global Burden of Cardiovascular Disease: The Role of Endothelial Function and Arterial Elasticity in Cardiovascular Disease as Novel and Emerging Biomarkers.
复制标题
心血管疾病的全球负担：内皮功能和动脉弹性作为新型和新兴生物标志物在心血管疾病中的作用。
DOI：
10.1007/s12170-010-0151-3
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发表时间：
2011
影响因子：
1.9
通讯作者：
Dudenbostel,Tanja
中科院分区：
文献类型：
--
作者：
Glasser,StephenP;Dudenbostel,Tanja
Some consider the measurements of arterial elasticity and flow-mediated dilation to be an indirect “biomarker” of endothelial dysfunction. As such, we describe the various uses of these techniques in the evaluation of the natural history of vascular disease. These measures are potential markers of disease, as abnormalities reflect changes in the integrity of vascular structure but occur prior to the manifestation of symptomatic cardiovascular events. In this review, the natural history of arterial elasticity is discussed, and the effects of aging and inflammation are reviewed. The role that arterial elasticity and flow-mediated dilation have in predicting future cardiovascular disease, and the effects of pharmacologic agents on these measures, is also reviewed.
