Transplantation of microencapsulated pancreatic human islets for therapy of diabetes mellitus. A preliminary report.
Transplantation of microencapsulated pancreatic human islets for therapy of diabetes mellitus. A preliminary report.
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DOI：
10.1097/00002480-199201000-00009
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发表时间：
1992-01-01
期刊：
影响因子：
--
通讯作者：
Calafiore, R
中科院分区：
文献类型：
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作者：
Calafiore, R
为了避免胰岛移植物的免疫破坏，将人胰岛放置在直接与血管相连的人工假体中，包裹在藻酸-聚氨基酸微胶囊中。三只狗和两名胰岛素依赖型糖尿病患者接受了微囊化人胰岛移植，植入动脉或AV假体旁路，无任何药物免疫抑制。移植物功能记录在所有受者的显着生产和维持血清C肽水平，虽然胰岛素的独立性始终实现只有一个三只狗，短暂的，在两个病人之一。在移植假体的检索，活的人胰岛被发现在微囊，其中大部分是自由分散在血管腔。人工血管可能代表了大量人类胰岛的合适植入部位，在半渗透性和生物相容性微胶囊中受到免疫保护，并且是治疗胰岛素依赖型糖尿病（IDDM）的新策略。
To circumvent immune destruction of pancreatic islet grafts, human islets were deposited, enveloped within algin-polyaminoacidic microcapsules, in artificial prostheses directly anastomosed to blood vessels. Three dogs and two patients with insulin-dependent diabetes received transplantations with microencapsulated human islets embodied in arterial or AV prosthesis bypasses without any pharmacologic immunosuppression. Graft function was documented in all recipients by significative production and sustenance of serum C-peptide levels, although insulin independence was consistently achieved in only one of three dogs and, transiently, in one of two patients. On retrieval of grafted prostheses, viable human islets were found in microcapsules, most of which were freely dispersed in the vascular chambers. Vascular prostheses may represent a suitable site of implantation for large numbers of human islets, immunoprotected in semipermeable and biocompatible microcapsules, and be a novel strategy for therapy of insulin-dependent diabetes mellitus (IDDM).