Sex hormones and the changes in adolescent male lipids: Longitudinal studies in a biracial cohort
Sex hormones and the changes in adolescent male lipids: Longitudinal studies in a biracial cohort
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DOI：
10.1067/mpd.2003.246
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发表时间：
2003-06-01
影响因子：
5.1
通讯作者：
Sprecher, DL
中科院分区：
文献类型：
--
作者：
Morrison, JA;Barton, BA;Sprecher, DL
目的探讨游离睾酮和雌二醇水平升高在青春期男性血脂变化中的作用。方法我们进行了一项为期3年的纵向观察研究，对251名10 - 15岁的黑人男孩和285名白人男孩进行了一年两次的访问。性激素、脂质参数和体成分测量根据标准方案获得。体重指数（kg/m(2)）被用来表征肥胖。结果白人男孩甘油三酯较高，高密度脂蛋白胆固醇（HDL-C）较低，载脂蛋白（apo）AI较低，载脂蛋白ob高于黑人男孩。在两个种族的男孩中，体重指数的增加与甘油三酯、低密度脂蛋白胆固醇、载脂蛋白ob的增加以及高密度脂蛋白c和载脂蛋白i的减少有关。在这个框架内，增加的游离睾酮与增加的载脂蛋白ob和降低的高密度脂蛋白c和载脂蛋白ai有关，而增加的雌二醇与增加的高密度脂蛋白c和降低的甘油三酯、低密度脂蛋白胆固醇和载脂蛋白ob有关。结论性类固醇激素的变化对血脂参数的变化有显著影响，游离睾酮水平升高具有动脉粥样硬化作用，雌二醇水平升高具有抗动脉粥样硬化作用。
Objective To determine the role of increasing free testosterone and estradiol in pubertal changes in male lipids.Methods We conducted a 3-year, longitudinal, observation study with biannual visits of 251 black and 285 white boys who were 10 to 15 years of age at enrollment. Sex hormones, lipid parameters, and body composition measures were obtained according to a standard protocol. The body mass index (kg/m(2)) was used to characterize obesity.Results White boys had higher triglycerides, lower high-density lipoprotein cholesterol (HDL-C), lower apolipoprotein (apo)AI, and higher apoB than black boys. In boys of both races, increased body mass index was associated with increases in triglycerides, low-density lipoprotein cholesterol, apoB and decreases in HDL-C and apoAII. Within this framework, increased free testosterone was associated with increased apoB and decreased HDL-C and apoAI, whereas increased estradiol was associated with increased HDL-C and decreased triglycerides, low-density lipoprotein cholesterol, and apoB.Conclusion Changes in sex steroid hormones have significant effects on changes in lipid parameters-increasing free testosterone levels has atherogenic effects and increasing estradiol has antiatherogenic effects..