A Study to Investigate the Role of Noncoding RNA miR146 Alpha as a Potential Biomarker in Prostate Cancer.
A Study to Investigate the Role of Noncoding RNA miR146 Alpha as a Potential Biomarker in Prostate Cancer.
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DOI：
10.30683/1927-7229.2022.11.03
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Banerjee, Hirendra Nath
中科院分区：
文献类型：
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作者：
Worthington, Myla;Aurelus, Chelsey;Banerjee, Narendra;Krauss, Christopher;Kahan, William;Banerjee, Satyendra;Gavin, Sherita;Bartlett, Victoria;Payne, Gloria;Rousch, Jeffrey;Verma, Mukesh;Sarkar, Fazlul;Banerjee, Hirendra Nath
前列腺癌的诊断和预后需要更多的生物标志物。MicroRNAs是一类非蛋白质编码的RNA分子，在包括前列腺癌在内的不同癌症中经常表达失调，有望成为诊断生物标志物和治疗靶点。在这里，我们描述了microRNA146a(miR-146a)的作用，它可以作为前列腺癌的诊断标记物，如本报告中提供的数据所示。此外，一项初步研究表明，miR-146a在不同种族的前列腺癌细胞系和组织中的表达存在差异。这份报告为理解前列腺癌的发生提供了一个新的视角。
There is a need for additional biomarkers for the diagnosis and prognosis of prostate cancer. MicroRNAs are a class of non-protein coding RNA molecules that are frequently dysregulated in different cancers including prostate cancer and show promise as diagnostic biomarkers and targets for therapy. Here we describe the role of micro RNA 146 a (miR-146a) which may serve as a diagnostic marker for prostate cancer, as indicated from the data presented in this report. Also, a pilot study indicated differential expression of miR-146a in prostate cancer cell lines and tissues from different racial groups. This report provides a novel insight into understanding the prostate carcinogenesis.