Z-score-based semi-quantitative analysis of the volume of the temporal horn of the lateral ventricle on brain CT images
Z-score-based semi-quantitative analysis of the volume of the temporal horn of the lateral ventricle on brain CT images
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基于Z分数的脑CT图像侧脑室颞角体积半定量分析
DOI：
10.1007/s12194-015-0335-0
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发表时间：
2016
影响因子：
1.6
通讯作者：
Tsai DY.
中科院分区：
文献类型：
--
作者：
Takahashi N;Kinoshita T;Ohmura T;Lee Y;Matsuyama E;Toyoshima H;Tsai DY.
侧脑室颞角（THLV）的体积在脑计算机断层扫描（CT）图像对神经系统的诊断是重要的。我们在这项研究中的目的是通过基于体素的形态计量学，开发基于az分数的半定量分析来估计THLV体积。使用az-score映射方法估计THLV体积，该方法包括四个主要步骤：解剖标准化、构建正常参考数据库、计算zscore和计算感兴趣体积（VOI）中的meanzscore。从THLV周围的VOI获得的CT值的平均值被用作THLV体积的指标。对50名受试者的CT扫描结果进行评估。为了评估该方法估计THLV体积的准确性，THLV体积由神经放射学家手动确定（作为参考体积）。使用所提出的方法，从50名受试者的每个THLV的VOI计算平均值。利用平均值与参考体积之间的关系评价了该方法的准确性。二次多项式回归方程显示，THLV的均值得分与参比容积有统计学意义（R2= 0.94， P< 0.0001）。在100个THLV中有92个（92%），区域平均得分的95%预测区间捕获了THLV的参考体积。基于thz分数的半定量分析具有定量估计CT图像上THLV体积的潜力。
The volume of the temporal horn of the lateral ventricle (THLV) on brain computed tomography (CT) images is important for neurologic diagnosis. Our purpose in this study was to develop az-score-based semi-quantitative analysis for estimation of the THLV volume by using voxel-based morphometry. The THLV volume was estimated by use of az-score mapping method that consisted of four main steps: anatomic standardization, construction of a normal reference database, calculation of thezscore, and calculation of the meanzscore in a volume of interest (VOI). A meanzscore of the CT value obtained from a VOI around the THLV was used as an index for the THLV volume. CT scans from 50 subjects were evaluated. For evaluation of the accuracy of this method for estimating the THLV volume, the THLV volume was determined manually by neuroradiologists (serving as the reference volume). A meanzscore was calculated from the VOI for each THLV of the 50 subjects by use of the proposed method. The accuracy of this method was evaluated by use of the relationship between the meanzscore and the reference volume. The quadratic polynomial regression equation demonstrated a statistically significant correlation between the meanzscore and the reference volume of the THLV (R2= 0.94;P< 0.0001). In 92 of 100 THLVs (92 %), the 95 % prediction interval of the regional meanzscore captured the reference volume of the THLV. Thez-score-based semi-quantitative analysis has the potential quantitatively to estimate the THLV volume on CT images.