A combination therapy of ethanol injection and radiofrequency ablation under general anesthesia for the treatment of hepatocellular carcinoma
A combination therapy of ethanol injection and radiofrequency ablation under general anesthesia for the treatment of hepatocellular carcinoma
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DOI：
10.3748/wjg.14.2037
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发表时间：
2008-04-01
影响因子：
4.3
通讯作者：
Kuriyama, Shigeki
中科院分区：
文献类型：
--
作者：
Kurokohchi, Kazutaka;Watanabe, Seishiro;Kuriyama, Shigeki
目的：总结全麻下腹腔镜无水乙醇注射射频消融术(L-EI-RFA)、胸腔镜术(T-EI-RFA)和开腹手术辅助EI-RFA(O-EI-RFA)治疗肝细胞癌的疗效。结果：全麻组、局麻组凝固性坏死的总能量、单位体积的凝固性坏死、边缘凝固性坏死的单位体积的应用能量明显大于L组，导致G组凝固性坏死灶体积较大，1年内局部复发率极低。结论：全麻下EI-RFA组肿瘤局部复发率极低。对于肝癌的治疗可能是有效的，因为在患者无痛条件下的治疗过程中可以应用更多的乙醇和能量。(C)2008年WJG。版权所有。
AIM: To summarize the effects of laparoscopic ethanol injection and radiofrequency ablation (L-EI-RFA), thoracoscopic (T-EI-RFA) and open-surgery assisted EI-RFA (O-EI-RFA) under general anesthesia for the treatment of hepatocellular carcinoma (HCC).METHODS: Time-lag performance of RFA after ethanol injection (Time-lag PEI-RFA) was performed in all cases. The volume of coagulated necrosis and the applied energy for total and per unit volume coagulated necrosis were examined in the groups treated under general (group G) or local anesthesia (group Q.RESULTS: The results showed that the total applied energy and the applied energy per unit volume of whole and marginal, coagulated necrosis were significantly larger in group G than those in the group L, resulting in a larger volume of coagulated necrosis in the group G. The rate of local tumor recurrence within one year was extremely low in group G.CONCLUSION: These results suggest that EI-RFA, under general anesthesia, may be effective for the treatment of HCC because a larger quantity of ethanol and energy could be applied during treatment under pain-free condition for the patients. (c) 2008 WJG. All rights reserved.