Cell-Type-Specific Sensorimotor Processing in Striatal Projection Neurons during Goal-Directed Behavior.
Cell-Type-Specific Sensorimotor Processing in Striatal Projection Neurons during Goal-Directed Behavior.
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DOI：
10.1016/j.neuron.2015.08.039
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发表时间：
2015-10-21
期刊：
影响因子：
16.2
通讯作者：
Petersen CC
中科院分区：
文献类型：
--
作者：
Sippy T;Lapray D;Crochet S;Petersen CC
目标导向的感觉运动转化驱动着哺乳动物行为的重要方面。纹状体被认为在基于奖励的学习和动作选择中起关键作用，接收多巴胺能感觉运动信号和多巴胺能奖励信号。在这里，我们获得了全细胞膜电位记录从背外侧纹状体的小鼠训练舔后，胡须偏转奖励喷口。纹状体投射神经元表现出较强的任务相关的调制，更多的去极化和动作电位发射击中试验相比，错过。直接通路纹状体黑质神经元，但不是间接通路纹状体苍白球神经元，表现出突出的早期感觉反应。直接途径的纹状体黑质神经元，但不是间接途径的纹状体苍白球神经元的光遗传刺激，很容易取代胡须刺激引起的舔反应。我们的数据是一致的，直接通路纹状体黑质神经元贡献了一个“去”的信号，目标导向的感觉运动转化，导致行动启动。行为小鼠纹状体投射神经元的膜电位记录检测到的触须刺激引起背外侧纹状体大的感觉运动反应纹状体黑质神经元而非纹状体体神经元的早期感觉诱发去极化纹状体黑质神经元而非纹状体体神经元的光遗传替代Sippy et al.测量进行简单目标定向感觉运动转换的头部受限小鼠纹状体中的细胞类型特异性膜电位动力学。他们的结果与直接通路纹状体黑质神经元传递快速“去”信号以启动动作一致。
Goal-directed sensorimotor transformation drives important aspects of mammalian behavior. The striatum is thought to play a key role in reward-based learning and action selection, receiving glutamatergic sensorimotor signals and dopaminergic reward signals. Here, we obtain whole-cell membrane potential recordings from the dorsolateral striatum of mice trained to lick a reward spout after a whisker deflection. Striatal projection neurons showed strong task-related modulation, with more depolarization and action potential firing on hit trials compared to misses. Direct pathway striatonigral neurons, but not indirect pathway striatopallidal neurons, exhibited a prominent early sensory response. Optogenetic stimulation of direct pathway striatonigral neurons, but not indirect pathway striatopallidal neurons, readily substituted for whisker stimulation evoking a licking response. Our data are consistent with direct pathway striatonigral neurons contributing a “go” signal for goal-directed sensorimotor transformation leading to action initiation. Membrane potential recordings of striatal projection neurons in behaving mice Detected whisker stimuli evoke large sensorimotor responses in dorsolateral striatum Early sensory-evoked depolarization in striatonigral but not striatopallidal neurons Optogenetic substitution by striatonigral but not striatopallidal neurons Sippy et al. measure cell-type-specific membrane potential dynamics in the striatum of head-restrained mice performing a simple goal-directed sensorimotor transformation. Their results are consistent with direct pathway striatonigral neurons delivering a fast “go” signal for action initiation.