Dynamic signaling for neural stem cell fate determination
Dynamic signaling for neural stem cell fate determination
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DOI：
10.4161/cam.3.1.7602
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发表时间：
2009-01
影响因子：
3.2
通讯作者：
S. Wen;Hong Li;Jia Liu
中科院分区：
文献类型：
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作者：
S. Wen;Hong Li;Jia Liu
中枢神经系统（CNS）的发育从神经干细胞（NSCs）开始，最终产生中枢神经系统的三种主要细胞类型（神经元、少突胶质细胞和星形胶质细胞）。NSCs以空间和时间相关的方式指定，成为空间异质性并产生逐渐限制的细胞类型库。在多种信号通路的影响下，哺乳动物NSCs在发育的不同时间点产生不同类型的细胞。这些通路以动态网络模式作用，通过调节一系列不同的转录因子的表达和活性来决定NSCs的命运，这些转录因子反过来又触发神经命运相关基因的转录。本文综述了NSC命运决定中的主要信号通路、转录因子及其相互作用。
Central nervous system (CNS) development starts from neural stem cells (NSCs) which ultimately give rise to the three major cell types (neurons, oligodendrocytes and astrocytes) of the CNS. NSCs are specified in space- and time-related fashions, becoming spatially heterogeneous and generating a progressively restricted repertoire of cell types. Mammalian NSCs produce different cell types at different time points during development under the influence of multiple signaling pathways. These pathways act in a dynamic web mode to determine the fate of NSCs via modulating the expression and activity of distinct set of transcription factors which in turn trigger the transcription of neural fate-associated genes. This review thus introduces the major signal pathways、transcription factors and their cross-talks and coordinative interactions in NSC fate determination.